Fluorescence enhanced sensing of cysteine based on reactive probe of naphthalene-quinoline

被引:0
|
作者
Dan Liu
Lin-E. Guo
Xiao Chen
Yan Xia
Xiaoli Hu
Shaohuang Weng
机构
[1] Sichuan University of Arts and Science,College of Chemistry and Chemical Engineering
[2] Yunnan Police Officer Academy,Key Laboratory
[3] Fujian Medical University,Department of Pharmaceutical Analysis, School of Pharmacy
来源
Journal of the Iranian Chemical Society | 2022年 / 19卷
关键词
Cysteine; Fluorescence detection; Naphthalene-quinoline; Twisted intramolecular charge transfer;
D O I
暂无
中图分类号
学科分类号
摘要
Naphthalene-quinoline (NQ), a reactive fluorescent probe, was synthesized based on 6-methoxy-2-acetylnaphthalene and quinoline-2-formaldehyde for highly sensitive recognition of cysteine (Cys). The absorption and fluorescence spectra of NQ showed significant changes toward Cys, suggesting the production of the covalent complex of NQ–Cys under physiological condition. The response mechanism of NQ to Cys was evaluated by nuclear magnetic resonance spectroscopy and high resolution mass spectrometry. It revealed that NQ reacted with Cys in the ratio of 1:1 with the Michael addition reaction, which blocked the effect of the twisted intramolecular charge transfer, resulting in the enhancement of the fluorescence intensity of NQ at 452 nm with variable controlled degrees. The detection of Cys using NQ as probe was achieved with the detection limit of 0.5 μM. Furthermore, the proposed method could be successfully applied to detect l-cysteine in real samples with good results.
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页码:2377 / 2382
页数:5
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