IL-21 and TGF-β are required for differentiation of human TH17 cells

被引：0
|
作者：
Li Yang
David E. Anderson
Clare Baecher-Allan
William D. Hastings
Estelle Bettelli
Mohamed Oukka
Vijay K. Kuchroo
David A. Hafler
机构：
[1] Center for Neurologic Diseases,Division of Molecular Immunology
[2] Brigham and Women’s Hospital,undefined
[3] Harvard Medical School,undefined
[4] Boston,undefined
[5] Massachusetts 02115,undefined
[6] USA,undefined
来源：
Nature | 2008年 / 454卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
TH17 cells (a subset of interleukin (IL)-17-producing T helper cells) are thought to contribute to the pathogenesis of a number of human autoimmune diseases. This study examines which cytokines are required for the production of IL-17A by memory and naive human CD4 T cells. The data demonstrate that transforming growth factor-β (TGF-β) is critical for the differentiation of TH17 cells from highly purified naive CD4+ T cells, but not necessary for induction of IL-17 from committed memory CD4+ T cells.
引用
收藏
页码：350 / 352
页数：2
相关论文
共 50 条
  • [21] Deltex-1 is indispensible for the IL-6 and TGF-β treatment-triggered differentiation of Th17 cells
    Tang, Zhengle
    Wang, Yuan
    Xing, Rui
    Zeng, Shan
    Di, Jingfang
    Xing, Feiyue
    CELLULAR IMMUNOLOGY, 2020, 356
  • [22] IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner
    Wei, Lai
    Laurence, Arian
    Elias, Kevin M.
    O'Shea, John J.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (48) : 34605 - 34610
  • [23] TGF-β indirectly favors the development of human Th17 cells by inhibiting Th1 cells
    Santarlasci, Veronica
    Maggi, Laura
    Capone, Manuela
    Frosali, Francesca
    Querci, Valentina
    De Palma, Raffaele
    Liotta, Francesco
    Cosmi, Lorenzo
    Maggi, Enrico
    Romagnani, Sergio
    Annunziato, Francesco
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2009, 39 (01) : 207 - 215
  • [24] Increased circulating Th17 cells and elevated serum levels of TGF-beta and IL-21 involved in human non-segmental vitiligo development
    Zhou, Li
    Shi, Yuling
    Li, Kai
    Hamzav, Iltefat
    Lim, Henry
    Mi, Qing-Sheng
    JOURNAL OF IMMUNOLOGY, 2013, 190
  • [25] Increased circulating Th17 cells and elevated serum levels of TGF-beta and IL-21 invovled in human non-segmental vitiligo development
    Zhou, L.
    Shi, Y.
    Li, K.
    Hamzavi, I.
    Gao, T.
    Lim, H.
    Mi, Q.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2013, 133 : S54 - S54
  • [26] Increased circulating Th17 cells and elevated serum levels of TGF-beta and IL-21 are correlated with human non-segmental vitiligo development
    Zhou, Li
    Shi, Yu-Ling
    Li, Kai
    Hamzavi, Iltefat
    Gao, Tian-Wen
    Huggins, Richard H.
    Lim, Henry W.
    Mi, Qing-Sheng
    PIGMENT CELL & MELANOMA RESEARCH, 2015, 28 (03) : 324 - 329
  • [27] IL-21 and IL-12 Inhibit Differentiation of Treg and TH17 Cells and Enhance Cytotoxicity of Peripheral Blood Mononuclear Cells in Patients With Cervical Cancer
    Tian, Yongju
    Yuan, Cunzhong
    Ma, Daoxin
    Zhang, Yan
    Liu, Yi
    Zhang, Wenjing
    Hou, Fei
    Cui, Baoxia
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2011, 21 (09) : 1672 - 1678
  • [28] TGF-β is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23
    Morishima, Noriko
    Mizoguchi, Izuru
    Takeda, Kiyoshi
    Mizuguchi, Junichiro
    Yoshimoto, Takayuki
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 386 (01) : 105 - 110
  • [29] In the presence of IL-21 human cord blood T cells differentiate to IL-10-producing Th1 but not Th17 or Th2 cells
    Doganci, Aysefa
    Birkholz, Julia
    Gehring, Stephan
    Puhl, Alexander G.
    Zepp, Fred
    Meyer, Claudius U.
    INTERNATIONAL IMMUNOLOGY, 2013, 25 (03) : 157 - 169
  • [30] TRAF6 inhibits Th17 differentiation and TGF-β-mediated suppression of IL-2
    Cejas, Pedro J.
    Walsh, Matthew C.
    Pearce, Erika L.
    Han, Daehee
    Harms, Gretchen M.
    Artis, David
    Turka, Laurence A.
    Choi, Yongwon
    BLOOD, 2010, 115 (23) : 4750 - 4757
12345