IL-21 and TGF-β are required for differentiation of human TH17 cells

被引：0
|
作者：
Li Yang
David E. Anderson
Clare Baecher-Allan
William D. Hastings
Estelle Bettelli
Mohamed Oukka
Vijay K. Kuchroo
David A. Hafler
机构：
[1] Center for Neurologic Diseases,Division of Molecular Immunology
[2] Brigham and Women’s Hospital,undefined
[3] Harvard Medical School,undefined
[4] Boston,undefined
[5] Massachusetts 02115,undefined
[6] USA,undefined
来源：
Nature | 2008年 / 454卷
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摘要：
TH17 cells (a subset of interleukin (IL)-17-producing T helper cells) are thought to contribute to the pathogenesis of a number of human autoimmune diseases. This study examines which cytokines are required for the production of IL-17A by memory and naive human CD4 T cells. The data demonstrate that transforming growth factor-β (TGF-β) is critical for the differentiation of TH17 cells from highly purified naive CD4+ T cells, but not necessary for induction of IL-17 from committed memory CD4+ T cells.
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页码：350 / 352
页数：2
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