A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity

被引:0
|
作者
Eleftherios Kostaras
Teresa Kaserer
Glorianne Lazaro
Sara Farrah Heuss
Aasia Hussain
Pedro Casado
Angela Hayes
Cihangir Yandim
Nicolaos Palaskas
Yi Yu
Brian Schwartz
Florence Raynaud
Yuen-Li Chung
Pedro R. Cutillas
Igor Vivanco
机构
[1] The Institute of Cancer Research,Division of Cancer Therapeutics
[2] The Institute of Cancer Research,Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics
[3] Center for Molecular Biosciences,Department of Pharmacology and Toxicology, Institute of Pharmacy
[4] University of Innsbruck,Centre for Haemato
[5] Queen Mary University of London,Oncology, Barts Cancer Institute
[6] David Geffen School of Medicine at UCLA,Division of Hematology and Oncology
[7] ArQule,Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging
[8] Inc. (a wholly-owned subsidiary of Merck & Co.,Department of Genetics and Bioengineering, Faculty of Engineering
[9] Inc.,undefined
[10] Kenilworth,undefined
[11] NJ,undefined
[12] USA),undefined
[13] The Institute of Cancer Research London and Royal Marsden Hospital,undefined
[14] Izmir University of Economics,undefined
来源
British Journal of Cancer | 2020年 / 123卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:542 / 555
页数:13
相关论文
共 50 条
  • [41] Design, synthesis, biological evaluation, and molecular docking of new benzofuran and indole derivatives as tubulin polymerization inhibitors
    El-Sayed, Naglaa F.
    El-Hussieny, Marwa
    Ewies, Ewies F.
    El Shehry, Mohamed F.
    Awad, Hanem M.
    Fouad, Marwa A.
    DRUG DEVELOPMENT RESEARCH, 2022, 83 (02) : 485 - 500
  • [42] Sulfated polysaccharides from marine diatoms: Insight into molecular characteristics and biological activity
    Miranda-Arizmendi, Valeria
    Fimbres-Olivarria, Diana
    Miranda-Baeza, Anselmo
    Rascon-Chu, Agustin
    Marquez-Escalante, Jorge
    Lizardi-Mendoza, Jaime
    Mendez-Encinas, Mayra A.
    Carvajal-Millan, Elizabeth
    AIMS BIOENGINEERING, 2024, 11 (01): : 110 - 129
  • [43] Design, synthesis and biological evaluation of a new series of imidazothiazole-hydrazone hybrids as dual EGFR and Akt inhibitors for NSCLC therapy
    Altintop, Mehlika Dilek
    Ertorun, Ipek
    Ciftci, Gulsen Akalin
    Ozdemir, Ahmet
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 276
  • [44] Biological activity tuning of antibacterial urotropine via co-crystallization: synthesis, biological activity evaluation and computational insight
    Tabbasum, Nida
    Varras, Panayiotis C.
    Arshad, Fizza
    Choudhary, Muhammad, I
    Yousuf, Sammer
    CRYSTENGCOMM, 2020, 22 (20) : 3439 - 3450
  • [45] Synthesis and Evaluation of Biological Activity of New Arylphosphoramidates
    Thebti, Amal
    Sanhoury, M. A. K.
    Ouzari, H-I.
    Barhoumi-slimi, T.
    BIOMED RESEARCH INTERNATIONAL, 2018, 2018
  • [46] Mycobacterium tuberculosis Low Molecular Weight Phosphatases (MPtpA and MPtpB): From Biological Insight to Inhibitors
    Fanzani, Luisa
    Porta, Federica
    Meneghetti, Fiorella
    Villa, Stefania
    Gelain, Arianna
    Lucarelli, Anna Paola
    Parisini, Emilio
    CURRENT MEDICINAL CHEMISTRY, 2015, 22 (27) : 3110 - 3132
  • [47] Synthesis and biological activity of potent, low molecular weight renin inhibitors
    SueirasDiaz, J
    Jones, DM
    Szelke, M
    Deinum, J
    Svensson, L
    Westerlund, C
    Sohtell, M
    JOURNAL OF PEPTIDE RESEARCH, 1997, 50 (04): : 248 - 261
  • [48] Histone deacetylase inhibitors: Molecular and biological activity as a premise to clinical application
    Santini, V.
    Gozzini, A.
    Ferrari, G.
    CURRENT DRUG METABOLISM, 2007, 8 (04) : 383 - 394
  • [49] Design, Synthesis and Biological Activity of New Carbamate Cholinesterase Inhibitors
    Malucka, Lucia Ungvarska
    Csollei, Jozef
    CHEMICKE LISTY, 2022, 116 (06): : 372 - 380
  • [50] Synthesis and biological evaluation of a new series of histone deacetylases inhibitors
    Jie Jiao Qiang Wang Hua Wei Zhu Hao Fang Wen Fang Xu~* School of Pharmaceutical Science
    Chinese Chemical Letters, 2008, (06) : 673 - 675