197 P75Ntr is Upregulated After Nmdar - Mediated Excitotoxic Brain Injury in Newborn Mice

被引：0
|
作者：
K Wegleiter
E Griesmaier
G Schlager
M Urbanek
M Keller
机构：
[1] Neonatology,Department of Paediatrics IV
[2] Neuropaediatrics and Metabolic Diseases,Department of Paediatrics
[3] Medical University Innsbruck,undefined
[4] Neonatology,undefined
[5] University Hospital Essen,undefined
来源：
Pediatric Research | 2010年 / 68卷
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摘要：
Background and aims: Perinatal brain injury, leading to lifelong neurological handicaps, depicts a major problem in preterm infants. It has been shown that activation of P75 neurotrophin receptor (P75NTR) plays a role in hypoxic-ischaemic and inflammation-mediated brain injury in adults. The role of P75NTR in the pathogenesis of perinatal brain injury is unknown. We hypothesized that activation of the NMDA (N-methyl-D-aspartate) receptor in the immature brain induces an upregulation of P75NTR and knock out of P75NTR decreases brain injury.
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页码：103 / 103
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