The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis

被引：0
|
作者：
Andrea J Berman
Benjamin M Akiyama
Michael D Stone
Thomas R Cech
机构：
[1] Howard Hughes Medical Institute,Department of Chemistry and Biochemistry
[2] University of Colorado,Department of Molecular
[3] Cell and Developmental Biology,Department of Chemistry and Biochemistry
[4] University of California,undefined
[5] University of California,undefined
来源：
Nature Structural & Molecular Biology | 2011年 / 18卷
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学科分类号：
摘要：
Telomerase uses its associated RNA as a template for processive addition of telomeric DNA repeats. Biochemistry and smFRET analysis are now used to investigate how the RNA template moves along the active site, revealing an accordion mechanism whereby the regions flanking the template alternate between extended and compacted forms.
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页码：1371 / 1375
页数：4
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