Platinum Complexes-Induced Cardiotoxicity of Isolated, Perfused Rat Heart: Comparison of Pt(II) and Pt(IV) Analogues Versus Cisplatin

被引:0
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作者
Miroslav M. Misic
Vladimir L. Jakovljevic
Zivadin D. Bugarcic
Vladimir I. Zivkovic
Ivan M. Srejovic
Nevena S. Barudzic
Dragan M. Djuric
Slobodan S. Novokmet
机构
[1] College for Specialized Studies in Belgrade,Department of Physiology, Faculty of Medical Sciences
[2] University of Kragujevac,Department of Chemistry, Faculty of Science
[3] University of Kragujevac,School of Medicine, Institute of Medical Physiology ‘‘Richard Burian’’
[4] University of Belgrade,Department of Pharmacy, Faculty of Medical Sciences
[5] University of Kragujevac,undefined
来源
Cardiovascular Toxicology | 2015年 / 15卷
关键词
Cardiotoxicity; Cisplatin; Isolated rat heart; Perfusion; Platinum(II) complexes; Platinum(IV) complexes;
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摘要
We have compared the cardiotoxicity of five platinum complexes in a model of isolated rat heart using the Langendorff technique. These effects were assessed via coronary flow (CF) and cardiac functional parameters. cis-Diamminedichloroplatinum(II) (cisplatin, CDDP), dichloro-(1,2-diaminocyclohexane)platinum(II) (Pt(II)DACHCl2), dichloro-(ethylenediamine)platinum(II) (Pt(II)ENCl2), tetrachloro-(1,2-diaminocyclohexane)platinum(IV) (Pt(IV)DACHCl4) and tetrachloro-(ethylenediamine)platinum(IV) (Pt(II)ENCl4) were perfused at increasing concentrations of 10−8, 10−7, 10−6, 10−5 and 10−4 M during 30 min. In this paper, we report that cisplatin-induced dose-dependent effects on cardiac contractility and coronary flow both manifested as decrease in cardiac contractile force (dP/dt)max, heart rate and significant reduction in CF. Pt(II)ENCl2, Pt(IV)ENCl2 and Pt(IV)DACHCl4 did induce dose-dependent response only in case of CF. Our results could be also important for better understanding dose-dependent side effects of potential metal-based anticancer drugs.
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页码:261 / 268
页数:7
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