Primary aldosteronism: diagnostic and treatment strategies

Primary aldosteronism is found in about one-tenth of people with hypertension. Following diagnosis, effective treatment is based on identification of the specific subtype of this condition. Of the various causes underlying primary aldosteronism, bilateral idiopathic hyperplasia and aldosterone-producing adenoma are the most common. In this Review, the authors describe the optimal approaches to detection and management of subtypes of aldosterone hypersecretion.