Pleomorphic (Giant and/or Spindle Cell) Carcinoma of Lung Shows a High Percentage of Variant CYP1A1*2

被引：0
|
作者：
Ronald M. Przygodzki
Michael N. Koss
Timothy J. O’leary
机构：
[1] The Armed Forces Institute of Pathology,Department of Cellular Pathology
[2] The Armed Forces Institute of Pathology,Department of Genetics
[3] Department of Cellular Pathology and Genetics,Armed Forces Institute of Pathology
来源：
Molecular Diagnosis | 2001年 / 6卷 / 2期
关键词：
lung carcinoma; CYP1A1; KRAS; DNA mutation;
D O I：
10.1007/BF03262040
中图分类号：
学科分类号：
摘要：
Background: Pleomorphic carcinoma (PC) of the lung is an aggressive epithelial neoplasm composed of giant and/or spindle tumor cells and associated with short survival. Most patients are cigarette smokers. The tumor susceptibility gene P-450 1A1 (CYP1A1) is involved in the activation of polycyclic aromatic hydrocarbons, including benzo[a]pyrene, producing DNA-damaging epoxides that lead to G:C→T:A point mutations. Isoleucine (Ile)-valine (Val) and Val-Val genotypes of the CYP1A1 exon 7 polymorphism are associated with an increased risk for lung cancer in certain populations.
引用
收藏
页码：109 / 115
页数：6
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