Experimental Evaluation of Rat Cord Blood as a Source of Stem Cells Stimulating Regeneration of the Bone Tissue

被引：0
|
作者：
A. V. Melnikova
A. G. Khasanov
A. I. Sendik
S. V. Sibiryak
机构：
[1] Bashkir State Medical University,
[2] Institute of Biochemistry and Genetics,undefined
[3] Ufa Research Center of the Russian Academy of Sciences,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2010年 / 149卷
关键词：
stem cells of the blood; bone regeneration;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We studied subpopulation structure of rat cord blood and its effects on regeneration of the bone tissue. In cord blood leukocytes, cell fractions with phenotypes CD45+/CD90−, CD45−/CD90+, CD34+/CD45+ were determined. The cells adhered to plastic during culturing and had a fibroblast-like morphology. Transplantation of rat cord blood cells into modeled femoral bone defects stimulated regeneration of the bone tissue and led to recovery of its anatomical integrity, which was confirmed by X-ray examination and histological analysis. No complete recovery of the bone structure was observed in controls (without cell implantation).
引用
收藏
页码：502 / 504
页数：2
相关论文
共 50 条
  • [21] The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering
    Mende, Wolfgang
    Goetzl, Rebekka
    Kubo, Yusuke
    Pufe, Thomas
    Ruhl, Tim
    Beier, Justus P.
    CELLS, 2021, 10 (05)
  • [22] Mesenchymal Stem Cells in Bone Tissue Regeneration and Application to Bone Healing
    Crha, Michal
    Necas, Alois
    Srnec, Robert
    Janovec, Jan
    Stehlik, Ladislav
    Rauser, Petr
    Urbanova, Lucie
    Planka, Ladislav
    Jancar, Josef
    Amler, Evzen
    ACTA VETERINARIA BRNO, 2009, 78 (04) : 635 - +
  • [23] Mesenchymal Stem Cells as a Potent Cell Source for Bone Regeneration
    Zomorodian, Elham
    Eslaminejad, Mohamadreza Baghaban
    STEM CELLS INTERNATIONAL, 2012, 2012
  • [24] Enhancement of in vivo bone regeneration efficacy of osteogenically undifferentiated human cord blood mesenchymal stem cells
    Kang, Jin Muk
    Kang, Sun-Woong
    La, Wan-Geun
    Yang, Yoon-Sun
    Kim, Byung-Soo
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2010, 93A (02) : 666 - 672
  • [25] Peculiarities of Using Stem Cells for Regeneration of the Bone and Cartilage Tissue
    Maiborodin, I. V.
    Shevela, A. I.
    Kolesnikov, I. S.
    Drovosekov, M. N.
    Toder, M. S.
    Shevela, A. A.
    Brombin, A. I.
    Beregovoy, E. A.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2011, 152 (01) : 112 - 119
  • [26] Peculiarities of Using Stem Cells for Regeneration of the Bone and Cartilage Tissue
    I. V. Maiborodin
    A. I. Shevela
    I. S. Kolesnikov
    M. N. Drovosekov
    M. S. Toder
    A. A. Shevela
    A. I. Brombin
    E. A. Beregovoy
    Bulletin of Experimental Biology and Medicine, 2011, 152 : 112 - 119
  • [27] Umbilical cord tissue is a robust source for mesenchymal stem cells with enhanced myogenic differentiation potential compared to cord blood
    Shivangi Mishra
    Jayesh Kumar Sevak
    Anamica Das
    G. Aneeshkumar Arimbasseri
    Shinjini Bhatnagar
    Suchitra D. Gopinath
    Scientific Reports, 10
  • [28] Umbilical cord tissue is a robust source for mesenchymal stem cells with enhanced myogenic differentiation potential compared to cord blood
    Mishra, Shivangi
    Sevak, Jayesh Kumar
    Das, Anamica
    Arimbasseri, G. Aneeshkumar
    Bhatnagar, Shinjini
    Gopinath, Suchitra D.
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [29] Bone and cartilage regeneration with the use of umbilical cord mesenchymal stem cells
    Klontzas, Michail E.
    Kenanidis, Eustathios I.
    Heliotis, Manolis
    Tsiridis, Eleftherios
    Mantalaris, Athanasios
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2015, 15 (11) : 1541 - 1552
  • [30] Comparison of mesenchymal stem cells from bone marrow, umbilical cord blood, and umbilical cord tissue in regeneration of a full-thickness tendon defect in vitro and in vivo
    Yea, Ji-Hye
    Kim, Yeasol
    Jo, Chris H.
    BIOCHEMISTRY AND BIOPHYSICS REPORTS, 2023, 34
12345