X-ray diffraction studies of 5-functionalized substituted 1,2,3,4-tetrahydropyrimidin-2-ones(thiones): I. Molecular structures of 5-acetyl-4-ethyl-6-methyl-1,2,3,4-tetrahydropyrimidine-2-thione, 5-acetyl-6-methyl-4-(4-methylphenyl)-1,2,3,4-tetrahydropyrimidine-2-thione, and 5-acetyl-4-(4-methoxyphenyl)-6-methyl-1,2,3,4-tetrahydropyrimidin-2-one

被引：0

作者：

G. V. Gurskaya

V. E. Zavodnik

A. D. Shutalev

机构：

[1] Russian Academy of Sciences,Éngelhardt Institute of Molecular Biology

[2] State Scientific Center,Karpov Research Institute of Physical Chemistry

[3] Lomonosov State Academy of Fine Chemical Technology,undefined

来源：

Crystallography Reports | 2003年 / 48卷

关键词：

Molecular Structure; Diffraction Study; Thiones; Conformational Feature; Tetrahydropyrimidine;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The structures of three 5-acetyl-1,2,3,4-tetrahydropyrimidin-2-ones(thiones), namely, 5-acetyl-4-ethyl-6-methyl-1,2,3,4-tetrahydropyrimidine-2-thione, 5-acetyl-6-methyl-4-(4-methylphenyl)-1,2,3,4-tetrahy-dropyrimidine-2-thione, and 5-acetyl-4-(4-methoxyphenyl)-6-methyl-1,2,3,4-tetrahydropyrimidin-2-one, which are potential medicinals, are studied by X-ray diffraction. The conformational features of the molecules studied are analyzed. For these compounds, the dependence of the conformation of the tetrahydropyrimidine ring on the orientation of the substituent at the C(4) atom with respect to the heterocycle is found.

引用

页码：92 / 97

页数：5

共 50 条

[31] Ethyl 4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate monohydrate
Das, Ushati
Chheda, Shardul B.
Pednekar, Suhas R.
Karambelkar, Narendra P.
Row, T. N. Guru
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O2488 - U3763
[32] Methyl 4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate monohydrate
Thenmozhi, M.
Kavitha, T.
Satyanarayana, V. S. V.
Vijayakumar, V.
Ponnuswamy, M. N.
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O1921 - U3509
[33] Crystal structure of ethyl 6-methyl-2-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Novina, J. J.
Vasuki, G.
Suresh, M.
Padusha, M. Syed Ali
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2015, 71 : O206 - +
[34] Ethyl 4-(2-bromo-5-fluorophenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Fun, Hoong-Kun
Jebas, Samuel Robinson
Babu, M.
Patil, P. S.
Kalluraya, B.
Dharmaprakash, S. M.
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1526 - U2616
[35] Ethyl 4-(furan-2-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Wang, Hong-Yun
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O2822 - U231
[36] Ethyl 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Fun, Hoong-Kun
Yeap, Chin Sing
Sujith, K. V.
Kalluraya, B.
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O1229 - U1393
[37] Thermodynamic properties of methyl 4-(4-methoxyphenyl)-6-methl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate in organic solutions
Ridka, O.
Matiychuk, V
Sobechko, I
Tyshchenko, N.
Novyk, M.
Sergeev, V
Goshko, L.
FRENCH-UKRAINIAN JOURNAL OF CHEMISTRY, 2019, 7 (02): : 1 - 8
[38] Ethyl 4-(2,4-difluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Fun, Hoong-Kun
Yeap, Chin Sing
Babu, M.
Kalluraya, B.
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O1188 - U1025
[39] 5-Acetyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidine-2(1H)-thione
Anuradha, N.
Thiruvalluvar, A.
Pandiarajan, K.
Chitra, S.
Butcher, R. J.
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O3036 - U109
[40] Ethyl 6-methyl-3-(2-methylprop-1-enyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Wang, Xi-Cun
Tang, Xue-Hong
Da, Yu-Xia
Zhang, Zhang
Quan, Zheng-Jun
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O2993 - U1027

← 1 2 3 4 5 →