Antibacterial properties of coordination compounds of silver and tryptophan

The antibacterial activity of a series of coordination compounds of silver (Ag) and tryptophan (Trp) with a Trp/Ag molar ratio of 1:1 [C(Trp)∈= ∈C(Ag)∈=∈0.001 M, C(Trp)∈=∈0.0204%, C(Ag)∈=∈0.0108%], 2:1 [C(Trp)∈=∈0.00133 M, C(Ag)∈=∈0.00067 M, C(Trp)∈=∈0.0272%, C(Ag)∈=∈0. 0072%], and 1:2 [C(Trp)∈=∈0.00067 M, C(Ag)∈=∈0.00133 M, C(Trp)∈=∈0.0136%, C(Ag)∈=∈0.0144%], and an aqueous solution of AgNO3 [C∈=∈0.002 M, C(Ag)∈=∈0.0216%] have been studied by the method of diffusion into agar. It is established that all compounds show a clearly pronounced antibacterial effect that depends on the silver concentration. © 2008 Springer Science+Business Media, Inc.