Earlier and broader roles of Mesp1 in cardiovascular development

被引：0
|
作者：
Yu Liu
机构：
[1] University of Houston,Department of Biology and Biochemistry
来源：
Cellular and Molecular Life Sciences | 2017年 / 74卷
关键词：
Stem cell; Cell fate; Mesoderm; Reprogramming; Cardiomyocyte;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mesoderm posterior 1 is one of earliest markers of the nascent mesoderm. Its best-known function is driving the onset of the cardiovascular system. In the past decade, new evidence supports that Mesp1 acts earlier with greater breadth in cell fate decisions, and through cell-autonomous and cell non-autonomous mechanisms. This review summarizes these new aspects, with an emphasis on the upstream and downstream regulation around Mesp1 and how they may guide cell fate reprogramming.
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页码：1969 / 1983
页数：14
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