Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling

被引:0
|
作者
Kai Yang
Daniel Bastardo Blanco
Geoffrey Neale
Peter Vogel
Julian Avila
Clary B. Clish
Chuan Wu
Sharad Shrestha
Sherri Rankin
Lingyun Long
Anil KC
Hongbo Chi
机构
[1] St Jude Children’s Research Hospital,Department of Immunology
[2] Hartwell Center for Bioinformatics and Biotechnology,Department of Pathology
[3] St Jude Children’s Research Hospital,undefined
[4] St Jude Children’s Research Hospital,undefined
[5] Metabolomics Platform,undefined
[6] Broad Institute of MIT and Harvard University,undefined
[7] Evergrande Center for Immunologic Diseases,undefined
[8] Brigham and Women’s Hospital,undefined
[9] Harvard Medical School,undefined
来源
Nature | 2017年 / 548卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
The tumour suppressor liver kinase B1 (LKB1) regulates the metabolic and functional fitness of regulatory T cells in the control of immune tolerance and homeostasis.
引用
收藏
页码:602 / 606
页数:4
相关论文
共 50 条
  • [21] LKB1 (XEEK1) regulates Wnt signalling in vertebrate development
    Ossipova, O
    Bardeesy, N
    DePinho, RA
    Green, JBA
    NATURE CELL BIOLOGY, 2003, 5 (10) : 889 - 894
  • [22] LKB1 (XEEK1) regulates Wnt signalling in vertebrate development
    Olga Ossipova
    Nabeel Bardeesy
    Ronald A. DePinho
    Jeremy B. A. Green
    Nature Cell Biology, 2003, 5 : 889 - 894
  • [23] LKB1 promotes metabolic flexibility in response to energy stress
    Parker, Seth J.
    Svensson, Robert U.
    Divakaruni, Ajit S.
    Lefebvre, Austin E.
    Murphy, Anne N.
    Shaw, Reuben J.
    Metallo, Christian M.
    METABOLIC ENGINEERING, 2017, 43 : 208 - 217
  • [24] Exogenous activation of LKB1/AMPK signaling induces G1 arrest in cells with endogenous LKB1 expression
    Liang, Xiaoyan
    Wang, Pilong
    Gao, Qing
    Tao, Xiaohong
    MOLECULAR MEDICINE REPORTS, 2014, 9 (03) : 1019 - 1024
  • [25] LKB1 and AMPK regulate Nptx2 expression and glutamate signalling in pancreatic beta cells
    Nguyen-Tu, M. -S.
    Kantor, C.
    Sayers, S.
    Pullen, T. J.
    Sun, G.
    Kone, M.
    Ibberson, M.
    Ferrer, J.
    Thorens, B.
    Swisa, A.
    Dor, Y.
    Hildebrandt, T.
    Uphues, I.
    Rutter, G. A.
    DIABETOLOGIA, 2014, 57 : S48 - S48
  • [26] LKB1 Coordinates Metabolic Pathways to Maintain Homeostasis of Haematopoietic Stem Cells and Regulate Erythropoiesis
    Zhang, Shijie
    Xu, Yuanlin
    Zhang, Mingming
    Zhang, Jingxin
    Jia, Peijun
    Li, Yudong
    Duan, Lulu
    Li, Yan
    Zhang, Huan
    Li, Yating
    Qu, Xiaoli
    Chen, Lixiang
    An, Xiuli
    BLOOD, 2021, 138
  • [27] LKB1 regulates macrophage metabolism and functional polarization in immunomodulation
    Yang, Jing
    Xu, Chengxian
    Lechner, Joseph
    Walls, Haley
    Yang, Kai
    JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
  • [28] LKB1 signalling attenuates early events of adipogenesis and responds to adipogenic cues
    Gormand, Amelie
    Berggreen, Christine
    Amar, Lahouari
    Henriksson, Emma
    Lund, Ingrid
    Albinsson, Sebastian
    Goransson, Olga
    JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2014, 53 (01) : 117 - 130
  • [29] Lkb1 aggravates diffuse large B-cell lymphoma by promoting the function of Treg cells and immune escape
    Xiuhua Su
    Tao Sun
    Meng Li
    Yuan Xia
    Mingying Li
    Dongmei Wang
    Fei Lu
    Jingjing Ye
    Chunyan Ji
    Journal of Translational Medicine, 20
  • [30] A new molecular target in colorectal cancer signalling:: The LKB1 tumour suppressor gene and Wnt signalling
    Spicer, J
    Rayter, S
    Ashworth, A
    BRITISH JOURNAL OF CANCER, 2004, 91 : S5 - S5