Multi-targeted Antisense Oligonucleotide Delivery by a Framework Nucleic Acid for Inhibiting Biofilm Formation and Virulence

被引：0
|
作者：
Yuxin Zhang
Xueping Xie
Wenjuan Ma
Yuxi Zhan
Chenchen Mao
Xiaoru Shao
Yunfeng Lin
机构：
[1] Sichuan University,State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology
来源：
Nano-Micro Letters | 2020年 / 12卷
关键词：
Biofilm; Framework nucleic acid; Multi-targeting; Antisense oligonucleotide; Delivery system;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A framework nucleic acid delivery system was developed through self-assembly, which can deliver antisense oligonucleotides against multiple targets in bacterial cells.The ASOs-tFNAs (750 nM) was found to simultaneously inhibit the expression of gtfBCD, gbpB, and ftf, and significantly reduce the extracellular polysaccharide synthesis and biofilm thickness.
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