Candidate-gene approaches for studying complex genetic traits: practical considerations

被引：0
|
作者：
Holly K. Tabor
Neil J. Risch
Richard M. Myers
机构：
[1] Stanford University School of Medicine,Department of Health Research and Policy, and the Department of Genetics
[2] Kaiser Permanente,Department of Genetics, Stanford University School of Medicine and the Division of Research
[3] Stanford University School of Medicine,Department of Genetics
来源：
Nature Reviews Genetics | 2002年 / 3卷
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摘要：
Association studies with candidate genes have been widely used for the study of complex diseases. However, this approach has been criticized because of non-replication of results and limits on its ability to include all possible causative genes and polymorphisms. These challenges have led to pessimism about the candidate-gene approach and about the genetic analysis of complex diseases in general. We believe that these criticisms can be usefully countered with an appeal to the principles of epidemiological investigation.
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页码：391 / 397
页数：6
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