Precise nanomedicine for intelligent therapy of cancer

被引：0

作者：

Huabing Chen

Zhanjun Gu

Hongwei An

Chunying Chen

Jie Chen

Ran Cui

Siqin Chen

Weihai Chen

Xuesi Chen

Xiaoyuan Chen

Zhuo Chen

Baoquan Ding

Qian Dong

Qin Fan

Ting Fu

Dayong Hou

Qiao Jiang

Hengte Ke

Xiqun Jiang

Gang Liu

Suping Li

Tianyu Li

Zhuang Liu

Guangjun Nie

Muhammad Ovais

Daiwen Pang

Nasha Qiu

Youqing Shen

Huayu Tian

Chao Wang

Hao Wang

Ziqi Wang

Huaping Xu

Jiang-Fei Xu

Xiangliang Yang

Shuang Zhu

Xianchuang Zheng

Xianzheng Zhang

Yanbing Zhao

Weihong Tan

Xi Zhang

Yuliang Zhao

机构：

[1] Soochow University,State Key Laboratory of Radiation Medicine and Protection, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences

[2] Chinese Academy of Sciences,Institute of High Energy Physics

[3] National Center for Nanoscience and Technology of China,CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience

[4] University of Chinese Academy of Sciences,Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry

[5] Chinese Academy of Sciences,Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, State Key Laboratory of Virology, and Institute for Advanced Studies

[6] University of Science and Technology of China,Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering

[7] Jilin Biomedical Polymers Engineering Laboratory,Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry

[8] Wuhan University,Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering

[9] Zhejiang University,Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio

[10] Wuhan University,Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province

[11] National Institutes of Health,Jiangsu Key Laboratory for Carbon

[12] Hunan University,Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials

[13] Soochow University,Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering

[14] Nanjing University,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health

[15] Xiamen University,Department of Chemistry

[16] Tsinghua University,National Engineering Research Center for Nanomedicine, College of Life Science and Technology

[17] Huazhong University of Science and Technology,Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at Bio/nano Interface, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute

[18] University of Florida,undefined

来源：

Science China Chemistry | 2018年 / 61卷

关键词：

nanomedicine; nanoparticles; cancer therapy; cancer imaging; intelligent therapy;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.

引用

页码：1503 / 1552

页数：49

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