A Perfused In Vitro Human iPSC-Derived Blood–Brain Barrier Faithfully Mimics Transferrin Receptor-Mediated Transcytosis of Therapeutic Antibodies

被引：0
|
作者：
Floriana Burgio
Carine Gaiser
Kevin Brady
Viviana Gatta
Reiner Class
Ramona Schrage
Laura Suter-Dick
机构：
[1] University of Applied Sciences and Arts Northwestern Switzerland (FHNW),Development Sciences
[2] UCB Biopharma SRL,Neuroscience Therapeutic Area
[3] UCB Biopharma SRL,undefined
来源：
Cellular and Molecular Neurobiology | 2023年 / 43卷 / 8期
关键词：
Induced pluripotent stem cells-derived brain microvascular endothelial cells; Microfluidic system; Blood–brain barrier; Receptor-mediated transcytosis; Transferrin receptor; Biologics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：4173 / 4187
页数：14
相关论文
共 50 条
  • [21] Applications of an isogenic human iPSC-derived blood-brain barrier (BBB) model
    Othman, A.
    Munn, C. A.
    Donegan, M. E.
    Burton, S.
    Livingston, M. K.
    Fiene, R. K.
    Tomotoshi, K.
    Hilcove, S. A.
    Liu, J.
    Vaidyanathan, R.
    Carlson, C. B.
    TOXICOLOGY LETTERS, 2023, 384 : S189 - S189
  • [22] Investigating receptor-mediated antibody transcytosis using blood-brain barrier organoid arrays
    Simonneau, Claire
    Duschmale, Martina
    Gavrilov, Alina
    Brandenberg, Nathalie
    Hoehnel, Sylke
    Ceroni, Camilla
    Lassalle, Evodie
    Kassianidou, Elena
    Knoetgen, Hendrik
    Niewoehner, Jens
    Villasenor, Roberto
    FLUIDS AND BARRIERS OF THE CNS, 2021, 18 (01)
  • [23] Receptor-mediated therapeutic transport across the blood-brain barrier
    Wang, Yun-Yan
    Lui, Philip C. W.
    Li, Jian Yi
    IMMUNOTHERAPY, 2009, 1 (06) : 983 - 993
  • [24] Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport
    Yajuan Shi
    Hyosung Kim
    Catherine A. Hamann
    Elizabeth M. Rhea
    Jonathan M. Brunger
    Ethan S. Lippmann
    Fluids and Barriers of the CNS, 19
  • [25] Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior
    Linville, Raleigh M.
    DeStefano, Jackson G.
    Sklar, Matt B.
    Xu, Zinnia
    Farrell, Alanna M.
    Bogorad, Max I.
    Chu, Chengyan
    Walczak, Piotr
    Cheng, Linzhao
    Mahairaki, Vasiliki
    Whartenby, Katharine A.
    Calabresi, Peter A.
    Searson, Peter C.
    BIOMATERIALS, 2019, 190 (24-37) : 24 - 37
  • [26] High Throughput Blood-brain Barrier Organoid Generation and Assessment of Receptor-Mediated Antibody Transcytosis
    Kassianidou, Elena
    Simonneau, Claire
    Gavrilov, Alina
    Villasenor, Roberto
    BIO-PROTOCOL, 2022, 12 (08):
  • [27] Strategies to identify, engineer, and validate antibodies targeting blood-brain barrier receptor-mediated transcytosis systems for CNS drug delivery
    Choi, Eun Seo
    Shusta, Eric, V
    EXPERT OPINION ON DRUG DELIVERY, 2023, 20 (12) : 1789 - 1800
  • [28] Nuclear receptor ligand screening in an iPSC-derived in vitro blood-brain barrier model identifies new contributors to leptin transport
    Shi, Yajuan
    Kim, Hyosung
    Hamann, Catherine A.
    Rhea, Elizabeth M.
    Brunger, Jonathan M.
    Lippmann, Ethan S.
    FLUIDS AND BARRIERS OF THE CNS, 2022, 19 (01)
  • [29] Synthetic Polymer Nanoparticles Functionalized with Different Ligands for Receptor-Mediated Transcytosis across the Blood-Brain Barrier
    Lu, Qian
    Cai, Xiaoli
    Zhang, Xian
    Li, Suiqiong
    Song, Yang
    Du, Dan
    Dutta, Prashanta
    Lin, Yuehe
    ACS APPLIED BIO MATERIALS, 2018, 1 (05): : 1687 - 1694
  • [30] TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia
    Jairaman, Amit
    McQuade, Amanda
    Granzotto, Alberto
    Kang, You Jung
    Chadarevian, Jean Paul
    Gandhi, Sunil
    Parker, Ian
    Smith, Ian
    Cho, Hansang
    Sensi, Stefano L.
    Othy, Shivashankar
    Blurton-Jones, Mathew
    Cahalan, Michael D.
    ELIFE, 2022, 11
12345