Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus

被引：278
|
作者：
Hong Y.-K. [1 ]
Foreman K. [2 ]
Shin J.W. [1 ]
Hirakawa S. [1 ]
Curry C.L. [2 ]
Sage D.R. [3 ]
Libermann T. [4 ]
Dezube B.J. [3 ]
Fingeroth J.D. [3 ]
Detmar M. [1 ]
机构：
[1] Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129
[2] Loyola University Medical Center, Maywood
[3] Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
[4] BIDMC Genomics Center, Department of Medicine, Harvard Medical School, Boston
来源：
Nature Genetics | 2004年 / 36卷 / 7期
关键词：
D O I：
10.1038/ng1383
中图分类号：
学科分类号：
摘要：
Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma-associated herpesvirus leads to their lymphatic reprogramming; induction of ∼70% of the main lymphatic lineage-specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.
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收藏
页码：683 / 685
页数：2
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