Genomic HLA profiles of MS in Hokkaido, Japan: important role of DPB1*0501 allele

被引：0

作者：

T. Fukazawa

S. Kikuchi

H. Sasaki

I. Yabe

R. Miyagishi

T. Hamada

K. Tashiro

机构：

[1] Hokuyukai Neurology Hospital,

[2] Niju Yon Ken 2-2-4-30,undefined

[3] Nishi-ku,undefined

[4] Sapporo 063-0802,undefined

[5] Japan e-mail: fukazawa@my.email.ne.jp,undefined

[6] Tel.: +81-11-6311161,undefined

[7] Fax: +81-11-6311163,undefined

[8] Department of Neurology,undefined

[9] Hokkaido University School of Medicine,undefined

[10] Kita 14-Nishi 5,undefined

[11] Kita-ku,undefined

[12] Sapporo 060-8638,undefined

[13] Japan,undefined

来源：

Journal of Neurology | 2000年 / 247卷

关键词：

Key words Multiple sclerosis; HLA-class II; HLA-DPB1; HLA-DQB1; Japanese;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The polymorphism of ¶the HLA class II genes was investigated in 97 patients with multiple sclerosis (MS) in Hokkaido, the northernmost main island of Japan. Of these, 80 patients were classified as having conventional MS and 17 ¶as having opticospinal MS (OS-MS). Our findings confirmed a previous report that the DPB1*0501 allele is positively associated with OS-MS ¶(P = 0.0043). The frequency of DPB1*0501 was also found to be higher in conventional MS patients than in controls (79% vs. 58%, ¶P = 0.0084), although the differences were not statistically significant. Our results indicate that OS-MS is a DPB1*0501-associated subgroup of MS, and that DPB1*0501 is also correlated with risk of conventional MS in Japanese.

引用

页码：175 / 178

页数：3

共 50 条

[31] Characterization of a novel HLA allele, DPB1*1049:01, in a pediatric patient with severe aplastic anemia
Chou-Wu, Po-Chien
Arnold, Paula Y.
HLA, 2020, 96 (06) : 758 - 759
[32] Resolving Ambiguities in Deceased Donor HLA Typing: Next Generation Sequencing's Role in DPB1 Allele Discrimination and Immunological Implications
Achram, Robert
Morris, Anna
Bray, Robert
Sullivan, H. Cliff
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2024, 162 : S163 - S164
[33] HLA-A, -B, -Cw, -DPB1, -DQA1, -DQB1 and -DRB1 allele frequencies in a population from Hyogo, Japan
Araki, N
HUMAN IMMUNOLOGY, 2004, 65 (9-10) : 996 - 997
[34] THE HLA DP LOCUS IN BONE-MARROW TRANSPLANTATION - PROBELESS GENOMIC TYPING OF THE DPB1 ALLELES
SORRENTINO, R
POTOLICCHIO, I
DAMATO, M
TOSI, R
BONE MARROW TRANSPLANTATION, 1993, 11 : 17 - 19
[35] Performance of HLA allele prediction methods in African Americans for class II genes HLA-DRB1, −DQB1, and –DPB1
Albert M Levin
Indra Adrianto
Indrani Datta
Michael C Iannuzzi
Sheri Trudeau
Paul McKeigue
Courtney G Montgomery
Benjamin A Rybicki
BMC Genetics, 15
[36] HLA-DPA1,-DPB1,-DQA1 and-DQB1 allele frequencies in a population from Gambia
Begovich, A
HUMAN IMMUNOLOGY, 2004, 65 (9-10) : 944 - 945
[37] HLA-DPA1,-DPB1,-DQA1 and-DQB1 allele frequencies in a population from Cameroon
Begovich, A
HUMAN IMMUNOLOGY, 2004, 65 (9-10) : 897 - 898
[38] The novel HLA class II allele, DPB1*1284:01, identified using next-generation sequencing
Yang, Guang
Abu-Khader, Ahmad
Burns, Caitlyn
Galaszkiewicz, Iwona
Berka, Noureddine
HLA, 2022, 100 (01) : 103 - 104
[39] HLA-DPA1,-DPB1,-DQA1 and-DQB1 Allele frequencies in a population from Tuva
Begovich, A
HUMAN IMMUNOLOGY, 2004, 65 (9-10) : 1185 - 1186
[40] HLA-A, -B, -Cw,-DPB1,-DQB1 and -DRB1 allele frequencies in a population from Belgium
Andrien, M
Dupont, E
HUMAN IMMUNOLOGY, 2004, 65 (9-10) : 865 - 866

← 1 2 3 4 5 →