4-Hydroxy-2-quinolones 120. Synthesis and structure of ethyl 2-hydroxy-4-oxo-4H-pyrido-[1,2-a]pyrimidine-3-carboxylate

被引：0
|
作者：
Ukrainets I.V. [1 ]
Bereznyakova N.L. [1 ]
Petyunin G.P. [1 ]
Tugaibei I.A. [1 ]
Rybakov V.B. [2 ]
Chernyshev V.V. [2 ]
Turov A.V. [3 ]
机构：
[1] National University of Pharmacy
[2] M. V. Lomonosov Moscow State University
[3] Taras Shevchenko National University
来源：
Chemistry of Heterocyclic Compounds | 2007年 / 43卷 / 6期
关键词：
2-aminopyridines; 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids; Esters; Heterocyclic tricarbonylmethane derivatives; X-ray analysis;
D O I：
10.1007/s10593-007-0119-5
中图分类号：
学科分类号：
摘要：
An improved method for the preparation and purification of ethyl 2-hydroxy-4-oxo-4H-pyrido[1,2-a]-pyrimidine-3-carboxylates is proposed. According to 1H and 13C NMR spectroscopic data the synthesized compounds exist in DMSO solution in the 2-hydroxy-4-oxo form while in the crystal (at least for the case of the unsubstituted derivative) X-ray analysis shows that it occurs in the bipolar 2,4-dioxo form. © 2007 Springer Science+Business Media, Inc.
引用
收藏
页码：729 / 739
页数：10
相关论文
共 50 条
  • [41] 4-Hydroxy-2-quinolones 150*. Efficient synthesis, structure, and biological activities of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkyl amides
    I. V. Ukrainets
    N. L. Bereznyakova
    V. A. Parshikov
    O. V. Gorokhova
    Chemistry of Heterocyclic Compounds, 2008, 44 : 1493 - 1499
  • [42] STRUCTURE AND REACTIVITY OF 2-METHYL-9-HYDROXY-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
    SMIRNOV, LD
    NIKITIN, SV
    CHERNISHEV, AI
    SOROKIN, AA
    LEZINA, VP
    ZABRODNYAYA, VG
    KAGANSKY, MM
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1992, (12): : 1660 - 1666
  • [43] Synthesis and reactions of 3-aroyl derivatives of 4-hydroxy-2-quinolones and 4-hydroxycoumarin
    Kappe, T
    Schnell, B
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1996, 33 (03) : 663 - 670
  • [44] 4-Hydroxy-2-quinolones 129. Synthesis and structure of 2-bromomethyl-4- carboxy-5-methyl-1,2-dihydrooxazolo-[3,2-a]quinolinium bromide
    Ukrainets I.V.
    Bereznyakova N.L.
    Parshikov V.A.
    Turov A.V.
    Chemistry of Heterocyclic Compounds, 2007, 43 (10) : 1269 - 1274
  • [45] Ethyl 4-(4-methoxyphenyl)-2-methyl-1,4dihydrobenzo[4,5] imidazo[1,2-a] pyrimidine-3-carboxylate
    Tang, Zi-Qiang
    Shao, Qing-Qing
    Zhou, Dian-Xiang
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2007, 63 : O450 - O452
  • [46] 4-Hydroxy-2-quinolones. 46. Esters of 1h-2-oxo-4-hydroxy-3-quinolineacetic acid
    Ukrainets I.V.
    Kamenetskaya O.L.
    Taran S.G.
    Petukhova I.Y.
    Voronina L.N.
    Chemistry of Heterocyclic Compounds, 2001, 37 (01) : 100 - 102
  • [47] 4-hydroxy-2-quinolones .32. Synthesis and antithyroid activity of 1H-2-oxo-3-(benzimidazolyl-2)-4-hydroxyquinoline thio analogs
    Ukrainets, IV
    Taran, SG
    Gorokhova, OV
    Marusenko, NA
    Turov, AV
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1997, (05): : 692 - 696
  • [48] 4-Hydroxy-2-quinolones 150. Efficient synthesis, structure, and biological activities of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkyl amides
    Ukrainets, I. V.
    Bereznyakova, N. L.
    Parshikov, V. A.
    Gorokhova, O. V.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2008, 44 (12) : 1493 - 1499
  • [49] 4-Hydroxy-2-quinolones 142. 4-Methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides as potential diuretics
    I. V. Ukrainets
    N. L. Bereznyakova
    V. A. Parshikov
    O. I. Naboka
    Chemistry of Heterocyclic Compounds, 2008, 44 : 178 - 183
  • [50] 4-hydroxy-2-quinolones - 140. Synthesis and diuretic activity of arylalkylamides of 4-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid
    Ukrainets, I. V.
    Bereznyakova, N. L.
    Parshikov, V. A.
    Kravchenko, V. N.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2008, 44 (01) : 64 - 72
12345