Kicking off sphingolipid biosynthesis: structures of the serine palmitoyltransferase complex

被引:0
|
作者
Binks W. Wattenberg
机构
[1] Virginia Commonwealth University School of Medicine,Department of Biochemistry and Molecular Biology
来源
Nature Structural & Molecular Biology | 2021年 / 28卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Structures of the human serine palmitoyltransferase complex reveal the overall assembly, regulatory mechanisms and substrate selectivity of this key enzyme in sphingolipid synthesis.
引用
收藏
页码:229 / 231
页数:2
相关论文
共 50 条
  • [31] Dynamics of sphingolipids and the serine palmitoyltransferase complex in rat oligodendrocytes during myelination[S]
    Davis, Deanna L.
    Mahawar, Usha
    Pope, Victoria S.
    Allegood, Jeremy
    Sato-Bigbee, Carmen
    Wattenberg, Binks W.
    JOURNAL OF LIPID RESEARCH, 2020, 61 (04) : 505 - 522
  • [32] A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis
    Hanada, K
    Hara, T
    Nishijima, M
    Kuge, O
    Dickson, RC
    Nagiec, MM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (51) : 32108 - 32114
  • [33] SPHINGOLIPID BIOSYNTHESIS BY RAT-LIVER CELLS - EFFECTS OF SERINE, FATTY-ACIDS AND LIPOPROTEINS
    MESSMER, TO
    WANG, E
    STEVENS, VL
    MERRILL, AH
    JOURNAL OF NUTRITION, 1989, 119 (04): : 534 - 538
  • [34] Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis
    Teng, Wendi
    Li, Yuan
    Du, Min
    Lei, Xingen
    Xie, Siyu
    Ren, Fazheng
    NUTRIENTS, 2019, 11 (05):
  • [35] Arabidopsis 56-Amino Acid Serine Palmitoyltransferase-Interacting Proteins Stimulate Sphingolipid Synthesis, Are Essential, and Affect Mycotoxin Sensitivity
    Kimberlin, Athen N.
    Majumder, Saurav
    Han, Gongshe
    Chen, Ming
    Cahoon, Rebecca E.
    Stone, Julie M.
    Dunn, Teresa M.
    Cahoon, Edgar B.
    PLANT CELL, 2013, 25 (11): : 4627 - 4639
  • [36] The serine palmitoyltransferase core subunit StLcb2 regulates sphingolipid metabolism and promotes Setosphaeria turcica pathogenicity by modulating appressorium development
    Li, Pan
    An, Zhenwu
    Sun, Hehe
    Meng, Yanan
    Hou, Lifeng
    Han, Xinpeng
    Feng, Shang
    Liu, Yuwei
    Shen, Shen
    Zeng, Fanli
    Dong, Jingao
    Hao, Zhimin
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 283
  • [37] SUPPRESSORS OF THE CA2+-SENSITIVE YEAST MUTANT (CSG2) IDENTIFY GENES INVOLVED IN SPHINGOLIPID BIOSYNTHESIS - CLONING AND CHARACTERIZATION OF SCS1, A GENE REQUIRED FOR SERINE PALMITOYLTRANSFERASE ACTIVITY
    ZHAO, C
    BEELER, T
    DUNN, T
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1994, 269 (34) : 21480 - 21488
  • [38] Homeostatic Regulation of Serine Palmitoyltransferase (SPT) is Mediated by a Direct Interaction of Ceramide with the SPT/ORMDL Complex
    Davis, Deanna
    Wattenberg, Binks
    FASEB JOURNAL, 2017, 31
  • [39] THE LCB2 GENE OF SACCHAROMYCES AND THE RELATED LCB1 GENE ENCODE SUBUNITS OF SERINE PALMITOYLTRANSFERASE, THE INITIAL ENZYME IN SPHINGOLIPID SYNTHESIS
    NAGIEC, MM
    BALTISBERGER, JA
    WELLS, GB
    LESTER, RL
    DICKSON, RC
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (17) : 7899 - 7902
  • [40] The Essential Structures of ISP-I that Influence Serine Palmitoyltransferase Inhibition in Chinese Hamster Ovary Cells
    Mizukoshi, Koji
    Matsumoto, Katsuo
    Hirose, Ryoji
    Fujita, Tetsuro
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2012, 35 (08) : 1349 - 1353