Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Likned Thiazole-1,2-isoxazole Derivatives

被引：0
|
作者：
T. Yakantham
R. Sreenivasulu
G. Alluraiah
M. B. Tej
R. Ramesh Raju
机构：
[1] Acharya Nagarjuna University,Department of Chemistry
[2] University College of Engineering (Autonomous),Department of Chemistry
[3] Jawaharlal Nehru Technological University,Department of Chemistry
[4] S V Arts and Science College,Department of Pharmacy
[5] Sri Ramachandra Institute of Higher Education and Research,undefined
来源：
Russian Journal of General Chemistry | 2019年 / 89卷
关键词：
triazole; thiazole; isoxazole; MTT assay; anticancer activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of novel 1,2,3-triazole linked thiazole-1,2-isoxazole derivatives has been designed, synthesized and characterized by 1H and 13C NMR, and mass spectral analysis. The compounds have been tested for their anticancer activity towards MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer), and A2780 (ovarian cancer) by using the MTT method using etoposide as the reference. Most of the tested compounds demonstrate good to moderate activity against all cell lines. The compounds 14b, 14e, 14g, and 14h are characterized by inhibitory activity stronger than that of etoposide.
引用
收藏
页码：2522 / 2527
页数：5
相关论文
共 50 条
  • [31] Synthesis, Anticancer Activity, and Molecular Docking of New 1,2,3-Triazole Linked Tetrahydrocurcumin Derivatives
    Duan, Meitao
    Mahal, Ahmed
    Alkouri, Anas
    Wang, Chen
    Zhang, Zhiqiang
    Ren, Jungang
    Obaidullah, Ahmad J.
    MOLECULES, 2024, 29 (13):
  • [32] Synthesis and Anticancer Activity of 11-azaartemisinin Derivatives Bearing 1,2,3-triazole Moiety
    Dung Tien Nguyen
    Thuong Hanh Ngo
    Hien Thu Tran
    Thao Phuong Dinh
    Phuong Thi Do
    Hau Ba Nguyen
    Linh Thi Phuong Tran
    Hanh My Ta
    Chemistry of Heterocyclic Compounds, 2021, 57 : 1037 - 1044
  • [33] Synthesis and discovery of novel 1,2,3-triazole based cabotegravir derivatives with potent anticancer activity
    Guo, Yajie
    Hou, Jingyu
    Wu, Hao
    Chen, Ying
    Liu, Guangnan
    Wang, Dan
    Wang, Huili
    Mao, Longfei
    Li, Sanqiang
    Wang, Tong
    JOURNAL OF MOLECULAR STRUCTURE, 2024, 1298
  • [34] An Efficient Synthesis of Some New Hydrazone Derivatives Containing 1,2,3-Triazole and Thiazole
    Ablajan, Keyume
    Wang Liju
    Tuoheti, Anagu
    LETTERS IN ORGANIC CHEMISTRY, 2013, 10 (10) : 715 - 721
  • [35] HERBICIDAL ACTIVITY OF 1,2,3-TRIAZOLE DERIVATIVES
    MESSORI, V
    BALDI, L
    BIANCHETTI, G
    CHIMICA & L INDUSTRIA, 1977, 59 (06): : 438 - 440
  • [36] Synthesis of glucosylated 1,2,3-triazole derivatives
    Chen, XM
    Li, ZJ
    Ren, ZX
    Huang, ZT
    CARBOHYDRATE RESEARCH, 1999, 315 (3-4) : 262 - 267
  • [37] Synthesis of glucosylated 1,2,3-triazole derivatives
    Carbohyd Res, 3-4 (262-267):
  • [38] Synthesis of ribosylated 1,2,3-triazole derivatives
    Ren, ZX
    Chen, XM
    Li, ZJ
    Huang, ZT
    HETEROATOM CHEMISTRY, 2003, 14 (06) : 487 - 490
  • [39] Synthesis of 1,2,3-triazole and isoxazole-linked pyrazole hybrids and their cytotoxic activity
    B. Madhavilatha
    Narjis Fatima
    Gowravaram Sabitha
    B. V. Subba Reddy
    J. S. Yadav
    Debanjan Bhattacharjee
    Nishant Jain
    Medicinal Chemistry Research, 2017, 26 : 1753 - 1763
  • [40] Synthesis of 1,2,3-triazole and isoxazole-linked pyrazole hybrids and their cytotoxic activity
    Madhavilatha, B.
    Fatima, Narjis
    Sabitha, Gowravaram
    Reddy, B. V. Subba
    Yadav, J. S.
    Bhattacharjee, Debanjan
    Jain, Nishant
    MEDICINAL CHEMISTRY RESEARCH, 2017, 26 (08) : 1753 - 1763
12345