Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Likned Thiazole-1,2-isoxazole Derivatives

被引：0
|
作者：
T. Yakantham
R. Sreenivasulu
G. Alluraiah
M. B. Tej
R. Ramesh Raju
机构：
[1] Acharya Nagarjuna University,Department of Chemistry
[2] University College of Engineering (Autonomous),Department of Chemistry
[3] Jawaharlal Nehru Technological University,Department of Chemistry
[4] S V Arts and Science College,Department of Pharmacy
[5] Sri Ramachandra Institute of Higher Education and Research,undefined
来源：
Russian Journal of General Chemistry | 2019年 / 89卷
关键词：
triazole; thiazole; isoxazole; MTT assay; anticancer activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of novel 1,2,3-triazole linked thiazole-1,2-isoxazole derivatives has been designed, synthesized and characterized by 1H and 13C NMR, and mass spectral analysis. The compounds have been tested for their anticancer activity towards MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer), and A2780 (ovarian cancer) by using the MTT method using etoposide as the reference. Most of the tested compounds demonstrate good to moderate activity against all cell lines. The compounds 14b, 14e, 14g, and 14h are characterized by inhibitory activity stronger than that of etoposide.
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页码：2522 / 2527
页数：5
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