Functionalized Au@Ag-Au nanoparticles as an optical and SERS dual probe for lateral flow sensing

被引:0
|
作者
Tingting Bai
Meng Wang
Min Cao
Juan Zhang
Kangzhen Zhang
Ping Zhou
Zhengxia Liu
Ying Liu
Zhirui Guo
Xiang Lu
机构
[1] Nanjing Medical University,Department of Geriatrics, The Second Affiliated Hospital, Key Laboratory for Aging & Disease
[2] Nantong University,School of Science
来源
Analytical and Bioanalytical Chemistry | 2018年 / 410卷
关键词
Lateral flow assay strip; Au nanoparticles; Au-Ag bimetallic nanoparticles; Surface-enhanced Raman scattering;
D O I
暂无
中图分类号
学科分类号
摘要
Lateral flow assay strips (LFASs) with Au nanoparticles (NPs) have been widely used as a probe for biomarkers in point-of-care testing; however, there still remain challenges in detection sensitivity and quantitative analysis. In this study, we developed a surface-enhanced Raman scattering (SERS)-based LFAS for quantitative analysis of a biomarker in the low concentration range. Moreover, apart from conventional Au NPs, three other types of citrate-capped Au-Ag bimetallic NPs: Au core with Ag shell NPs (Au@Ag NPs), rattle-like Au core in Ag-Au shell NPs (Au@Ag-Au NPs) and Ag-Au NPs were prepared and functionalized, and their solution-based SERS activities were comprehensively studied by experimental measurement and theoretical analysis. The results clearly indicated that the citrate-capped Au@Ag-Au NPs exhibited the highest SERS activity among the probes tested. Au@Ag-Au NPs were used as both optical and SERS probes in a SERS-based LFAS. In the presence of the analyte at high concentrations, a purple color appeared in the test zone. Highly sensitive and quantitative analysis was realized by measurement of SERS signals from the test lines. One of the most specific markers for cardiac injury, cardiac troponin I (cTnI), was chosen as the detection model. The detection limit of the SERS-based LFAS for cardiac troponin I was 0.09 ng/mL, lowered by nearly 50 times compared with visual results, and could be further lowered by optimization. These results demonstrated that the SERS-based LFAS using citrate-capped Au@Ag-Au NPs as probes can be a powerful tool for highly sensitive and quantitative detection of biomarkers.
引用
收藏
页码:2291 / 2303
页数:12
相关论文
共 50 条
  • [41] Ethanol Sensing Properties of Au-functionalized NiO Nanoparticles
    Park, Sunghoon
    Kheel, Hyejoon
    Sun, Gun-Joo
    Hyun, Soong Keun
    Park, Sang Eon
    Lee, Chongmu
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2016, 37 (05): : 713 - 719
  • [42] Cubic Nonlinear Optical Properties of Ag Nanoparticles and Ag/Au Coreshells
    Ma, Seong-Min
    Seo, JaeTae
    Kim, WanJoong
    Heo, Jinha
    Austin, Jasmine
    Yang, Qiguang
    Tabibi, Bagher
    Temple, Doyle
    Yun, WanSoo
    Jung, SungSoo
    Han, Sang Woo
    Yu, William
    INTERNATIONAL SYMPOSIUM ON ADVANCED NANODEVICES AND NANOTECHNOLOGY, 2008, 109
  • [43] Super bright luminescent Ag and Au nanoparticles for imaging and sensing
    Dai, Hai-Lung
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
  • [44] SERS study of L-tryptophan adsorbed on Au/Ag nanoparticles surfaces
    Padilla, Amira C.
    Hernandez, Samuel P.
    Jusino, Bianca M.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [45] Ultrasensitive and reproducible SERS platform of coupled Ag grating with multibranched Au nanoparticles
    Kalachyova, Yevgeniya
    Mares, David
    Jerabek, Vitezslav
    Ulbrich, Pavel
    Lapcak, Ladislav
    Svorcik, Vaclav
    Lyutakov, Oleksiy
    PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2017, 19 (22) : 14761 - 14769
  • [46] Dependence of SERS enhancement on the chemical composition and structure of Ag/Au hybrid nanoparticles
    Chaffin, Elise
    O'Connor, Ryan T.
    Barr, James
    Huang, Xiaohua
    Wang, Yongmei
    JOURNAL OF CHEMICAL PHYSICS, 2016, 145 (05):
  • [47] Electrical Sensing of Au Nanoparticles Manipulated by an Optical Vortex
    Nakatsuka, Ryoji
    Yanai, Syuhei
    Nakajima, Kichitaro
    Doi, Kentaro
    Kawano, Satoyuki
    JOURNAL OF PHYSICAL CHEMISTRY C, 2021, 125 (17): : 9507 - 9515
  • [48] Evaluation of Morphological and Optical Properties of Ag, Au, and Ag@Au Nanoparticles Synthesized via Laser Ablation
    Abass, Noor al-huda A.
    Jawad, Muslim F.
    Haider, Adawiya J.
    Lasers in Manufacturing and Materials Processing, 2024, 11 (04) : 931 - 945
  • [49] Spectral indications of interaction of functionalized photochromic compounds with Ag and Au nanoparticles
    Barachevskii, V. A.
    Kobeleva, O. I.
    Valova, T. M.
    Ait, A. O.
    Kol'tsova, L. S.
    Shienok, A. I.
    Zaichenko, N. L.
    Laptev, A. V.
    Khodonov, A. A.
    Kuznetsova, O. Yu.
    Dudinov, A. A.
    Lichitskii, B. V.
    Krayushkin, M. M.
    THEORETICAL AND EXPERIMENTAL CHEMISTRY, 2012, 48 (01) : 14 - 20
  • [50] Green synthesis of proanthocyanidins-functionalized Au/Ag bimetallic nanoparticles
    Deng, Shixian
    Zhao, Baihan
    Xing, Yayan
    Shi, Yuzhe
    Fu, Yujie
    Liu, Zhiguo
    GREEN CHEMISTRY LETTERS AND REVIEWS, 2021, 14 (01) : 43 - 48