Implications of mitochondrial DNA mutations in human induced pluripotent stem cells

被引：0

作者：

Valerio Carelli

Michio Hirano

José Antonio Enríquez

Patrick F. Chinnery

机构：

[1] University of Bologna,Department of Biomedical and Neuromotor Sciences

[2] IRCCS Istituto delle Scienze Neurologiche di Bologna,Department of Neurology

[3] Programma di Neurogenetica,Department of Clinical Neurosciences, School of Clinical Medicine

[4] Columbia University Irving Medical Center,Medical Research Council Mitochondrial Biology Unit

[5] Centro Nacional de Investigaciones Cardiovasculares Carlos III,undefined

[6] Cenro de Investigacion Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES),undefined

[7] University of Cambridge,undefined

[8] Cambridge Biomedical Campus,undefined

[9] University of Cambridge,undefined

[10] Cambridge Biomedical Campus,undefined

来源：

Nature Reviews Genetics | 2022年 / 23卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Single-cell analyses in recent years have shown major differences in the transcriptome between individual cells in the same induced pluripotent stem cell-derived clones. Although these differences are in part attributable to genetic and epigenetic modifications of the nuclear genome, emerging evidence suggests that variants in mitochondrial DNA also play a pivotal role.

引用

页码：69 / 70

页数：1

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