Small-molecule activators of AMP-activated protein kinase as modulators of energy metabolism

被引：0
|
作者：
Novikova D.S. [1 ]
Garabadzhiu A.V. [1 ]
Melino G. [1 ]
Barlev N.A. [1 ,2 ]
Tribulovich V.G. [1 ]
机构：
[1] St. Petersburg State Institute of Technology (Technical University), 26 Moskovskii prosp., St. Petersburg
[2] Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretskii prosp, St. Petersburg
来源：
Russian Chemical Bulletin | 2015年 / 64卷 / 7期
基金：
俄罗斯基础研究基金会; 俄罗斯科学基金会;
关键词：
AMPK activators; AMP—activated protein kinase; Drug design; Energy metabolism;
D O I：
10.1007/s11172-015-1036-x
中图分类号：
学科分类号：
摘要：
Activated protein kinase (AMPK) is a key regulator of energy balance at both the cellular and wholebody levels. The activation of AMPK has a considerable potential in the therapy of a number of metabolic disorders as well as cancer. The achievements in the develop ment of smallmolecule activators of AMPK are reviewed. © 2015 Springer Science+Business Media, Inc.
引用
收藏
页码：1497 / 1517
页数：20
相关论文
共 50 条
  • [21] AMP-activated protein kinase activators have compound and concentration-specific effects on brain metabolism
    Achanta, Lavanya B.
    Thomas, Donald S.
    Housley, Gary D.
    Rae, Caroline D.
    JOURNAL OF NEUROCHEMISTRY, 2024, 168 (05) : 677 - 692
  • [22] Screening methods for AMP-activated protein kinase modulators: a patent review
    Kim, Joungmok
    Shin, Joonsoo
    Ha, Joohun
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2015, 25 (03) : 261 - 277
  • [23] Sensing of energy and nutrients by AMP-activated protein kinase
    Hardie, D. Grahame
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 2011, 93 (04): : 891S - 896S
  • [24] SENSING OF ENERGY AVAILABILITY BY THE AMP-ACTIVATED PROTEIN KINASE
    Hardie, David Grahame
    McBride, Andrew
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009, 59 : 61 - 61
  • [25] AMP-activated Protein Kinase in the Control of Cardiac Metabolism and Remodeling
    Sandrine Horman
    Christophe Beauloye
    Jean-Louis Vanoverschelde
    Luc Bertrand
    Current Heart Failure Reports, 2012, 9 (3) : 164 - 173
  • [26] AMP-activated protein kinase: role in metabolism and therapeutic implications
    Schimmack, Greg
    DeFronzo, Ralph A.
    Musi, Nicolas
    DIABETES OBESITY & METABOLISM, 2006, 8 (06): : 591 - 602
  • [27] Computer-Aided Drug Design for AMP-Activated Protein Kinase Activators
    Wang, Zhanli
    Huo, Jianxin
    Sun, Lidan
    Wang, Yongfu
    Jin, Hongwei
    Yu, Hui
    Zhang, Liangren
    Zhou, Lishe
    CURRENT COMPUTER-AIDED DRUG DESIGN, 2011, 7 (03) : 214 - 227
  • [28] AMP-activated protein kinase connects cellular energy metabolism to KATP channel function
    Yoshida, Hidetada
    Bao, Li
    Kefaloyianni, Eirini
    Taskin, Eylem
    Okorie, Uzoma
    Hong, Miyoun
    Dhar-Chowdhury, Piyali
    Kaneko, Michiyo
    Coetzee, William A.
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2012, 52 (02) : 410 - 418
  • [29] REGULATION OF RENAL METABOLISM BY THE AMP-ACTIVATED PROTEIN KINASE (AMPK)
    Choy, S.
    Fraser, S.
    Cook, N.
    Van Denderen, B.
    Gleich, K.
    Katerdos, M.
    Mount, P.
    Kemp, B.
    Power, D.
    NEPHROLOGY, 2009, 14 : A1 - A1
  • [30] Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism
    Carling, David
    Viollet, Benoit
    CELL METABOLISM, 2015, 21 (06) : 799 - 804
12345