Microbiota metabolites as agonists for the orphan receptor GPRC5A

被引：0
|
作者：
机构：
来源：
Nature Chemical Biology | 2023年 / 19卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We used chemical proteomics to identify candidate protein targets of indole metabolites in mammalian cells. We discovered that microbiota-derived and synthetic aromatic monoamines can activate recruitment of β-arrestin to the orphan receptor GPRC5A. Specific microbiota species that express amino acid decarboxylases were found to produce aromatic monoamine agonists for GPRC5A.
引用
收藏
页码：1183 / 1184
页数：1
相关论文
共 50 条
  • [11] GPRC5A acts as a potent oncogene in pancreatic cancer
    Zhou, Honglei
    Telonis, Aristeidis
    Jing, Yi
    Jimbo, Masaya
    Blanco, Fernando
    Londin, Eric
    Brody, Jonathan
    Rigoutsos, Isidore
    CANCER RESEARCH, 2016, 76
  • [12] GPRC5A promotes paclitaxel resistance and glucose content in NSCLC
    Wang, Yan
    Gao, Liang
    Wang, Feiyu
    Yu, Cunjun
    Chen, Chen
    Xia, Chunwei
    ANTI-CANCER DRUGS, 2024, 35 (07) : 606 - 614
  • [13] RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A
    Lukas Richter
    Viktoria Oberländer
    Gudula Schmidt
    Scientific Reports, 10
  • [14] RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A
    Richter, Lukas
    Oberlaender, Viktoria
    Schmidt, Gudula
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [15] Expression patterns of the G protein-coupled receptor, GPRC5A, in human malignant pleural mesothelioma
    Fujimoto, Junya
    Kadara, Humam
    Fukuoka, Junya
    Aoe, Keisuke
    Fujimoto, Nobukazu
    Kishimoto, Takumi
    Inai, Kouki
    Hiroshima, Kenzo
    Suraokar, Milind
    Tsao, Anne
    Mehran, Reza
    CANCER RESEARCH, 2012, 72
  • [16] Role of GPRC5A in Human Airway Smooth Muscle Remodeling
    Hamrick, S. K.
    Thompson, M.
    Lee, K.
    Drake, L. Y.
    Venkatachalem, S.
    Pabelick, C. M.
    Prakash, Y.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2024, 209
  • [17] Knockdown of GPRC5A inhibits cell proliferation, migration and invasion in osteosarcoma
    Wang, Y. J.
    Lin, S. H.
    Chen, L.
    Qiu, H. W.
    Wang, J. X.
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2021, 35 (01): : 59 - 65
  • [18] GPRC5A promotes lung colonization of esophageal squamous cell carcinoma
    Zhou, Hongyu
    Tan, Licheng
    Zhang, Baifeng
    Kwong, Dora Lai Wan
    Wong, Ching Ngar
    Zhang, Yu
    Ru, Beibei
    Lyu, Yingchen
    Siu, Kin To Hugo
    Luo, Jie
    Yang, Yuma
    Liu, Qin
    Chen, Yixin
    Zhang, Weiguang
    He, Chaohui
    Jiang, Peng
    Qin, Yanru
    Liu, Beilei
    Guan, Xin-Yuan
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [19] 肿瘤相关基因GPRC5A研究进展附视频
    林昀
    李琦
    高勇
    肿瘤, 2013, (01) : 86 - 90
  • [20] EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer
    Xiaofeng Lin
    Shuangshuang Zhong
    Xiaofeng Ye
    Yueling Liao
    Feng Yao
    Xiaohua Yang
    Beibei Sun
    Jie Zhang
    Qi Li
    Yong Gao
    Yifan Wang
    Jingyi Liu
    Baohui Han
    Y Eugene Chin
    Binhua P Zhou
    Jiong Deng
    Molecular Cancer, 13
12345