Microbiota metabolites as agonists for the orphan receptor GPRC5A

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Nature Chemical Biology | 2023年 / 19卷
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We used chemical proteomics to identify candidate protein targets of indole metabolites in mammalian cells. We discovered that microbiota-derived and synthetic aromatic monoamines can activate recruitment of β-arrestin to the orphan receptor GPRC5A. Specific microbiota species that express amino acid decarboxylases were found to produce aromatic monoamine agonists for GPRC5A.
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页码：1183 / 1184
页数：1
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