Inflammasome-derived IL-1β production induces nitric oxide–mediated resistance to Leishmania

被引：0
|
作者：
Djalma S Lima-Junior
Diego L Costa
Vanessa Carregaro
Larissa D Cunha
Alexandre L N Silva
Tiago W P Mineo
Fredy R S Gutierrez
Maria Bellio
Karina R Bortoluci
Richard A Flavell
Marcelo T Bozza
João S Silva
Dario S Zamboni
机构：
[1] Molecular e Bioagentes Patogêncios,Departmento de Biologia Celular
[2] Universidade de São Paulo,Departmento de Bioquímica e Imunologia
[3] Ribeirão Preto,Departmento de Imunologia
[4] São Paulo,Departmento de Ciências Biológicas e Centro de Terapia Celular e Molecular
[5] Brazil.,Department of Immunobiology
[6] Faculdade de Medicina de Ribeirão Preto,undefined
[7] Universidade de São Paulo,undefined
[8] Ribeirão Preto,undefined
[9] São Paulo,undefined
[10] Brazil.,undefined
[11] Instituto de Microbiologia,undefined
[12] Universidade Federal do Rio de Janeiro,undefined
[13] Universidade Federal de São Paulo,undefined
[14] Yale University School of Medicine,undefined
[15] Howard Hughes Medical Institute,undefined
[16] Yale University School of Medicine,undefined
[17] Present addresses: Instituto de Ciências Biomédicas,undefined
[18] Universidade Federal de Uberlândia,undefined
[19] Uberlândia,undefined
[20] Minas Gerais,undefined
[21] Brazil (T.W.P.M.),undefined
[22] and School of Medicine,undefined
[23] Antonio Nariño University,undefined
[24] Bogotá,undefined
[25] Colombia (F.R.S.G.).,undefined
来源：
Nature Medicine | 2013年 / 19卷
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摘要：
Activation of inflammasomes has been implicated in sensing pathogens. Now Dario Zamboni and colleagues report that the Nlrp3 inflammasome has a key role in restricting replication of Leishmania parasites in macrophages and in mice by triggering interleukin-1A–dependent induction of nitric oxide, a crucial mediator of defense against Leishmania.
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页码：909 / 915
页数：6
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