Novel autosomal recessive non-syndromic hearing impairment locus (DFNB71) maps to chromosome 8p22–21.3

被引：0

作者：

Muhammad Salman Chishti

Kwanghyuk Lee

Merry-Lynn McDonald

Muhammad Jawad Hassan

Muhammad Ansar

Wasim Ahmad

Suzanne M Leal

机构：

[1] Quaid-I-Azam University,Department of Biochemistry

[2] Baylor College of Medicine,Department of Molecular and Human Genetics

来源：

Journal of Human Genetics | 2009年 / 54卷

关键词：

8p22–21.3; autosomal recessive non-syndromic hearing impairment; DFNB71; Pakistan;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A novel ARNSHI (autosomal recessive non-syndromic hearing impairment) locus, DFNB71, was localized to 8p22–21.3. To map the locus, a whole-genome scan was carried out using DNA samples from a consanguineous seven-generational Pakistani family with profound prelingual ARNSHI. A maximum multipoint LOD score of 4.2 occurred at marker D8S261. The DFNB71 region of homozygosity and 3-unit support interval is flanked by markers D8S1130 and D8S1786. This region has a genetic distance of 19.1 cM and contains 10.6 Mb of sequence.

引用

页码：141 / 144

页数：3

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