Novel autosomal recessive non-syndromic hearing impairment locus (DFNB71) maps to chromosome 8p22–21.3

被引：0
|
作者：
Muhammad Salman Chishti
Kwanghyuk Lee
Merry-Lynn McDonald
Muhammad Jawad Hassan
Muhammad Ansar
Wasim Ahmad
Suzanne M Leal
机构：
[1] Quaid-I-Azam University,Department of Biochemistry
[2] Baylor College of Medicine,Department of Molecular and Human Genetics
来源：
Journal of Human Genetics | 2009年 / 54卷
关键词：
8p22–21.3; autosomal recessive non-syndromic hearing impairment; DFNB71; Pakistan;
D O I：
暂无
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学科分类号：
摘要：
A novel ARNSHI (autosomal recessive non-syndromic hearing impairment) locus, DFNB71, was localized to 8p22–21.3. To map the locus, a whole-genome scan was carried out using DNA samples from a consanguineous seven-generational Pakistani family with profound prelingual ARNSHI. A maximum multipoint LOD score of 4.2 occurred at marker D8S261. The DFNB71 region of homozygosity and 3-unit support interval is flanked by markers D8S1130 and D8S1786. This region has a genetic distance of 19.1 cM and contains 10.6 Mb of sequence.
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页码：141 / 144
页数：3
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