The spindle: a dynamic assembly of microtubules and motors

被引：0
|
作者：
Torsten Wittmann
Anthony Hyman
Arshad Desai
机构：
[1] The Scripps Research Institute,Department of Cell Biology
[2] Max Planck Institute for Molecular Cell Biology and Genetics,Department of Cell Biology
[3] European Molecular Biology Laboratory,undefined
来源：
Nature Cell Biology | 2001年 / 3卷
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学科分类号：
摘要：
In all eukaryotes, a microtubule-based structure known as the spindle is responsible for accurate chromosome segregation during cell division. Spindle assembly and function require localized regulation of microtubule dynamics and the activity of a variety of microtubule-based motor proteins. Recent work has begun to uncover the molecular mechanisms that underpin this process. Here we describe the structural and dynamic properties of the spindle, and introduce the current concepts regarding how a bipolar spindle is assembled and how it functions to segregate chromosomes.
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页码：E28 / E34
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