Chongmyungtang attenuates kainic acid-induced seizure and mortal effect in the mouse

被引：0
|
作者：
Kyung-Jin Jang
Kyou-Heung Lee
Sang-Lin Kim
Dong-Young Choi
Beom-Kyu Park
Doo-Hyun Im
Yong-Joon Cho
Wang-Kee Jhoo
Hyoung-Chun Kim
机构：
[1] Boryung Pharmaceutical Central Research Institute,College of Pharmacy
[2] Kangwon National University,undefined
来源：
Archives of Pharmacal Research | 1997年 / 20卷
关键词：
Chongmyungtang; Neuroprotective effect; Kainic acid-induced neurotoxicity;
D O I：
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中图分类号：
学科分类号：
摘要：
TheChongmyungtang (CMT; the combination ofAcorus gramineus, polygala tenuifolia andPoria cocos) has been recognized to possess the preventive effect against several neurologic disorders in human. In this study, we examined the effect of CMT on the three parameters associated with kainic acid (KA)-induced neurotoxicities; seizure/mortality, increased fos-related antigen (FRA) and glial fibrillary acidic protein (GFAP) expression. KA induced vigorous convulsions lasting 4–6 hr. Pretreatments with CMT before KA injection significantly reduced the seizure intensity as well as the mortality. CMT pretreatments also attenuated the KA-induced increase in FRA/GFAP expression in the hippocampus. These results suggest that CMT has a neuroprotective effect against KA-induced neurotoxicities.
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页码：375 / 378
页数：3
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