Synthesis of derivatives of 8-cyano-6-ethoxycarbonyl-3-hydroxy-5- methylimidazo[1,2-a]pyridine and 9-alkoxycarbonyl- (or 9-carboxy)-3- ethoxycarbonyl-2-methyl-10H-benzo[b]-1,8-naphthyridine-5-one from the reaction of 2-chloro-5-ethoxycarbonyl-6-methylnicotinonitrile with amino acids

被引：0

作者：

Deyanov A.B. ^{[1
]}

Konshin M.E. ^{[1
]}

机构：

[1] Perm State Pharmaceutical Academy, Perm 614990, Russia

来源：

Chemistry of Heterocyclic Compounds | 2004年 / 40卷 / 4期

关键词：

10H-benzo[b]-1,8-naphthyridin-5-ones; 2-(2carboxyanilino)nicotinonitriles; imidazo[1,2-a]pyridines;

D O I：

10.1023/B:COHC.0000033548.10379.02

中图分类号：

学科分类号：

摘要：

2-Substituted 8-cyano-6-ethoxycarbonyl-3-hydroxy-5-methylimidazo[1,2-a] pyridine was formed from the interaction of 2-chloro-5-ethoxycarbonyl-6- methylnicotinonitrile with α-amino acids in DMF. The same nitrile on boiling with anthranilic acid or its esters in butanol gave, respectively, 2-(2-carboxyanilino)- or 2-(2-alkoxycarbonylanilino)-5-ethoxycarbonyl-6- methylnicotinonitriles which cyclized on heating in PPA to give 9-alkoxycarbonyl(or 9-carboxy)-3-ethoxycarbonyl-2-methyl-10H-benzo[b]-1,8- naphthyridin-5-ones.

引用

页码：510 / 515

页数：5

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