Synthesis of derivatives of 8-cyano-6-ethoxycarbonyl-3-hydroxy-5- methylimidazo[1,2-a]pyridine and 9-alkoxycarbonyl- (or 9-carboxy)-3- ethoxycarbonyl-2-methyl-10H-benzo[b]-1,8-naphthyridine-5-one from the reaction of 2-chloro-5-ethoxycarbonyl-6-methylnicotinonitrile with amino acids

被引：0
|
作者：
Deyanov A.B. [1 ]
Konshin M.E. [1 ]
机构：
[1] Perm State Pharmaceutical Academy, Perm 614990, Russia
来源：
Chemistry of Heterocyclic Compounds | 2004年 / 40卷 / 4期
关键词：
10H-benzo[b]-1,8-naphthyridin-5-ones; 2-(2carboxyanilino)nicotinonitriles; imidazo[1,2-a]pyridines;
D O I：
10.1023/B:COHC.0000033548.10379.02
中图分类号：
学科分类号：
摘要：
2-Substituted 8-cyano-6-ethoxycarbonyl-3-hydroxy-5-methylimidazo[1,2-a] pyridine was formed from the interaction of 2-chloro-5-ethoxycarbonyl-6- methylnicotinonitrile with α-amino acids in DMF. The same nitrile on boiling with anthranilic acid or its esters in butanol gave, respectively, 2-(2-carboxyanilino)- or 2-(2-alkoxycarbonylanilino)-5-ethoxycarbonyl-6- methylnicotinonitriles which cyclized on heating in PPA to give 9-alkoxycarbonyl(or 9-carboxy)-3-ethoxycarbonyl-2-methyl-10H-benzo[b]-1,8- naphthyridin-5-ones.
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页码：510 / 515
页数：5
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