Cytomegalovirus Vaccines: Current Status and Future Prospects

被引:0
|
作者
K. M. Anderholm
C. J. Bierle
M. R. Schleiss
机构
[1] University of Minnesota Medical School,Division of Pediatric Infectious Diseases and Immunology, Department of Pediatrics, Center for Infectious Diseases and Microbiology Translational Research
来源
Drugs | 2016年 / 76卷
关键词
Bacterial Artificial Chromosome; Hematopoietic Stem Cell Transplantation; HCMV Infection; Neutralize Antibody Titer; Neutralize Antibody Response;
D O I
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中图分类号
学科分类号
摘要
Congenital human cytomegalovirus (HCMV) infection can result in severe and permanent neurological injury in newborns, and vaccine development is accordingly a major public health priority. HCMV can also cause disease in solid organ transplant (SOT) and hematopoietic stem-cell transplant (HSCT) recipients, and a vaccine would be valuable in prevention of viremia and end-organ disease in these populations. Currently there is no licensed HCMV vaccine, but progress toward this goal has been made in recent clinical trials. A recombinant HCMV glycoprotein B (gB) vaccine has been shown to have some efficacy in prevention of infection in young women and adolescents, and has provided benefit to HCMV-seronegative SOT recipients. Similarly, DNA vaccines based on gB and the immunodominant T-cell target, pp65 (ppUL83), have been shown to reduce viremia in HSCT patients. This review provides an overview of HCMV vaccine candidates in various stages of development, as well as an update on the current status of ongoing clinical trials. Protective correlates of vaccine-induced immunity may be different for pregnant woman and transplant patients. As more knowledge emerges about correlates of protection, the ultimate licensure of HCMV vaccines may reflect the uniqueness of the target populations being immunized.
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页码:1625 / 1645
页数:20
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