Recent advances in carbohydrate-based paclitaxel delivery systems

被引：0

作者：

Azar Ramezanpour

Legha Ansari

Vahid Rahimkhoei

Sina Sharifi

Ashkan Bigham

Zohre Mehri Lighvan

Jafar Rezaie

Sławomir Szafert

GholamReza Mahdavinia

Ali Akbari

Esmaiel Jabbari

机构：

[1] Isfahan University of Technology,Department of Chemistry

[2] Urmia University of Medical Sciences,Cellular and Molecular Research Center, Cellular and Molecular Medicine Research Institute

[3] Urmia University of Medical Sciences,Solid Tumor Research Center, Cellular and Molecular Medicine research Institute

[4] Massachusetts Eye and Ear and Schepens Eye Research Institute,Disruptive Technology Laboratory, Department of Ophthalmology

[5] Harvard Medical School,Department of Polymer Processing

[6] Institute of Polymers,Faculty of Chemistry

[7] Composites and Biomaterials,Polymer Research Laboratory, Department of Chemistry, Faculty of Science

[8] National Research Council (IPCB-CNR),Department of Chemical Engineering

[9] Iran Polymer and Petrochemical Institute,undefined

[10] University of Wrocław,undefined

[11] University of Maragheh,undefined

[12] University of South Carolina,undefined

来源：

Polymer Bulletin | 2024年 / 81卷

关键词：

Drug delivery; Carbohydrate polymers; Cancer therapy; Paclitaxel;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Paclitaxel (PTX) as the most important member of the taxane family is used against a wide range of cancers including breast, ovarian and lung cancers. However, the effectiveness of PTX in clinical practice is limited by its low water solubility and permeability in biological tissues. To address these limitations, PTX is formulated with Cremophor EL and dehydrated ethanol, known as Taxol®. Due to the adverse side effects of the formulation, efforts have been made in recent years to develop alternative PTX formulations. Polysaccharides, due to their low toxicity and biocompatibility, biodegradability, and ease of chemical modification are an excellent alternative to Cremophor EL for formulating PTX. This review focuses on recent advances to develop PTX formulations based on polysaccharides.

引用

页码：1043 / 1069

页数：26

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