Myo-inositol-1-phosphate (MIP) synthase inhibition: in-vivo study in rats

被引：0
|
作者：
H. Einat
F. Tian
R. H. Belmaker
J. W. Frost
机构：
[1] University of Minnesota,Department of Pharmacy Practice and Pharmaceutical Education, College of Pharmacy
[2] Michigan State University,Department of Chemistry
[3] Ben-Gurion University of the Negev,undefined
来源：
Journal of Neural Transmission | 2008年 / 115卷
关键词：
Keywords: Bipolar disorder; animal model; inositol depletion; mood stabilizers;
D O I：
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中图分类号：
学科分类号：
摘要：
Lithium and valproate are the prototypic mood stabilizers and have diverse structures and targets. Both drugs influence inositol metabolism. Lithium inhibits IMPase and valproate inhibits MIP synthase. This study shows that MIP synthase inhibition does not replicate or augment the effects of lithium in the inositol sensitive pilocarpine-induced seizures model. This lack of effects may stem from the low contribution of de-novo synthesis to cellular inositol supply or to the inhibition of the de-novo synthesis by lithium itself.
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页码：55 / 58
页数：3
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