Antituberculotic Activity of 5-Aryl(Hetaryl)-Methylidene- 2,4,6-Pyrimidine-2,4,6(1H,3H,5H)-Triones and 5-(2-Chloropropylidene)-2,4,6-Pyrimidine-2,4,6(1H,3H,5H)-Triones

被引：0
|
作者：
M. Yu. Yushin
A. G. Tyrkov
A. V. Lutsenko
L. V. Saroyants
G. N. Genatullina
A. K. Ayupova
机构：
[1] Astrakhan State Medical University,
[2] Tatishchev Astrakhan State University,undefined
[3] Astrakhan State Technical University,undefined
来源：
Pharmaceutical Chemistry Journal | 2023年 / 57卷
关键词：
5-aryl(hetaryl)methylidene-2,4,6-pyrimidine-2,4,6(1; ,3; ,5; )-triones; 5-(2-chloropropylidene)-2,4,6-pyrimidine-2,4,6(1; ,3; ,5; )-triones; antileprotic activity; antituberculotic activity; minimum inhibitory and bactericidal concentrations;
D O I：
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学科分类号：
摘要：
The effect of 5-aryl(hetaryl)methylidene-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones and 5-(2-chloropropylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones on the viability of laboratory strain M. tuberculosis H37Rv was studied. The minimum inhibitory and bactericidal concentrations and the acute toxicity in mice have been determined. Compounds XIII, XIV, XVII, and XIX had the greatest antituberculotic activity for M. tuberculosis H37Rv, indicating they were promising for further studies aimed at creating effective antituberculotic drugs.
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页码：214 / 217
页数：3
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