Locked nucleic acids (LNA) and medical applications

被引：0
|
作者：
Henrik Ørum
Andreas Wolter
Lars Kongsbak
机构：
[1] Bøgealle 3,Santaris Pharma A/S.
[2] Georg-Heyken-Str,Proligo GmbH
[3] Exiqon A/S,undefined
来源：
Letters in Peptide Science | 2003年 / 10卷
关键词：
affinity; antisense; biodistribution; capture probes; cellular uptake; detection-by-hybridisation; LNA primers; Locked Nucleic Acids (LNA); multiplex PCR; nuclease resistance; RNaseH recruiment; specificity; toxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Locked Nucleic Acid (LNA) is a novel, third generation DNA analogue that has the potentialto impact strongly on the future development of a diversity of nucleic acid based technologies.The present chapter reviews the known biochemical properties of LNA and exemplifies how thesehave been used to improve both DNA diagnostic technologies and antisense therapeutics.
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页码：325 / 334
页数：9
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