A New Ursane-Type Triterpenoid from the Leaves of Rhododendron dauricum with Cytotoxic Activity

被引：0
|
作者：
Chao Ye
Mei Jin
Jinfeng Sun
Jiaming Wang
Sainan Li
Wei Zhou
Gao Li
机构：
[1] Yanbian University College of Pharmacy,Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education
[2] Yanbian University Hospital,undefined
来源：
Chemistry of Natural Compounds | 2021年 / 57卷 / 2期
关键词：
Ericaceae; triterpenoid; cytotoxic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new ursane-type triterpenoid, 20-taraxastene-22α-methoxy-3β-ol (1) together with nine known triterpenoids (2–10), was isolated from the leaves of Rhododendron dauricum L. Their structures were established from spectroscopic data (1D, 2D NMR, and HR-ESI-MS) and comparison with reported values. Among the isolates, compounds 1 and 8 were found in the family Ericaceae for the first time, and compounds 5, 6, and 10 from this species for the first time. All the isolated compounds were evaluated for their cytotoxic activities against three human cancer cells; compound 1 exhibited better cytotoxic activity against A549, HeLa, and SK-Hep1 cells than the other compounds with IC50 values of 34.04 ± 1.01, 64.04 ± 1.75, and 44.04 ± 0.05 μM, respectively.
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页码：327 / 330
页数：3
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