Facile synthesis of 3-substituted quinazoline-2,4-dione and 2,3-di-substituted quinazolinone derivatives

被引：0

作者：

Mahmoud Farouk

Salman A. Alrokayan

Ahamad Imran

Khalid M. Abu-Salah

Mohamed Ghazzali

Khalid A. Al-Farhan

Salem El-Gohary

Mamdouh Adly

机构：

[1] Salman Bin Abdalaziz University,College of Sciences & Humanity studies

[2] King Saud University,Centre of Excellence in Biotechnology Research

[3] King Saud University,Research Chair of Targeting and Treatment of Cancer Using Nanoparticles, King Abdullah Institute for Nanotechnology

[4] King Saud University,Chemistry Department, College of Science

[5] South Valley University,Chemistry Department, Faculty of Science

来源：

Chemical Papers | 2013年 / 67卷

关键词：

3-nitrophthalic acid anhydride; -hydroxy-3-nitrophthalimide; -sulphonyloxy-3-nitrophthalimide; 3-substitued quinazoline-2,4(1; ,3; )-diones; 2,3-disubstituted quinazolinones;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

3-Substituted quinazoline-2,4(1H,3H)-dione and 2,3-di-substituted quinazolineone derivatives attract considerable interest due to their pharmacological properties. In this paper, we report the synthesis of N-substituted-3-nitrophthalimide derivatives II–III, the reactions of phthalimide III with amines, hydrazines, and amino acid derivatives to synthesise a small library of 3-substituted-5-nitroquinazoline-2,4(1H,3H)-diones IV–XIV and 2,3-di-substituted-6-nitro-quinazolineones XVIII–XIX.

引用

页码：229 / 235

页数：6

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