Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

被引：0

作者：

María Soler Artigas

Daan W Loth

Louise V Wain

Sina A Gharib

Ma'en Obeidat

Wenbo Tang

Guangju Zhai

Jing Hua Zhao

Albert Vernon Smith

Jennifer E Huffman

Eva Albrecht

Catherine M Jackson

David M Evans

Gemma Cadby

Myriam Fornage

Ani Manichaikul

Lorna M Lopez

Toby Johnson

Melinda C Aldrich

Thor Aspelund

Inês Barroso

Harry Campbell

Patricia A Cassano

David J Couper

Gudny Eiriksdottir

Nora Franceschini

Melissa Garcia

Christian Gieger

Gauti Kjartan Gislason

Ivica Grkovic

Christopher J Hammond

Dana B Hancock

Tamara B Harris

Adaikalavan Ramasamy

Susan R Heckbert

Markku Heliövaara

Georg Homuth

Pirro G Hysi

Alan L James

Stipan Jankovic

Bonnie R Joubert

Stefan Karrasch

Norman Klopp

Beate Koch

Stephen B Kritchevsky

Lenore J Launer

Yongmei Liu

Laura R Loehr

Kurt Lohman

Ruth J F Loos

机构：

[1] University of Leicester,Department of Health Sciences

[2] University of Leicester,Department of Genetics

[3] Erasmus MC,Department of Epidemiology

[4] Inspectorate of Healthcare,Department of Medicine

[5] Center for Lung Biology,Division of Therapeutics and Molecular Medicine

[6] University of Washington,Division of Nutritional Sciences

[7] University of Washington,Department of Twin Research and Genetic Epidemiology

[8] Nottingham Respiratory Biomedical Research Unit,Department of Public Health Sciences, Division of Biostatistics and Epidemiology

[9] University Hospital of Nottingham,Department of Psychology

[10] Cornell University Ithaca,Department of Thoracic Surgery

[11] King's College London,Division of Epidemiology

[12] London,Department of Biostatistics

[13] Discipline of Genetics,Department of Epidemiology

[14] Faculty of Medicine,Department of Health and Human Services

[15] Memorial University of Newfoundland,Department of Epidemiology and Biostatistics

[16] St. John's,Department of Medical and Molecular Genetics

[17] Medical Research Council (MRC) Epidemiology Unit,Department of Epidemiology

[18] Institute of Metabolic Science,Department of Functional Genomics

[19] Addenbrooke's Hospital,Department of Pulmonary Physiology and Sleep Medicine/West Australian Sleep Disorders Research Institute

[20] Icelandic Heart Association,Department of Respiratory Medicine

[21] University of Iceland,Department of Internal Medicine B

[22] MRC Human Genetics Unit,Department of Biostatistical Sciences, Division of Public Health Sciences

[23] Institute of Genetics and Molecular Medicine,Department of Statistics

[24] Western General Hospital,Department of Medicine

[25] Institute of Genetic Epidemiology,Department of Surgery and Pathology

[26] Helmholtz Zentrum München-German Research Center for Environmental Health,Department of Public Health and Community Medicine

[27] School of Medicine,Division of Epidemiology and Public Health

[28] University of St. Andrews,Department of Respiratory Medicine

[29] St. Andrews,Department of Epidemiology and Population Health

[30] Scotland,Department of Epidemiology and Public Health

[31] UK.,Division of Genetic Epidemiology, Department of Medical Genetics

[32] MRC Centre for Causal Analyses in Translational Epidemiology,Department of Statistics

[33] School of Social and Community Medicine,Department of Pulmonology

[34] University of Bristol,Department of Internal Medicine

[35] Genetic Epidemiology and Biostatistics Platform,Division of Pulmonary Medicine

[36] Ontario Institute for Cancer Research,Department of Medicine

[37] Prosserman Centre for Health Research,Department of Epidemiology

[38] Samuel Lunenfeld Research Institute,Department of Primary Care and Population Health

[39] Brown Foundation Institute of Molecular Medicine,Division of Population Health Sciences and Education

[40] University of Texas at Houston,Department of Genetics

[41] Human Genetics Center,Division of Preventive Medicine

[42] School of Public Health,Department of Medicine, Division of Internal Medicine

[43] University of Texas at Houston,Department of Public Health

[44] Center for Public Health Genomics,Department of Children

[45] University of Virginia,Department of Health Sciences

[46] University of Virginia,Department Of Chronic Disease Prevention

[47] Centre for Cognitive Ageing and Cognitive Epidemiology,Division of Aging, Department of Medicine

[48] The University of Edinburgh,Department of Clinical Physiology

[49] The University of Edinburgh,Department of Respiratory Medicine

[50] Clinical Pharmacology and the Genome Centre,Department of Internal Medicine B

来源：

Nature Genetics | 2011年 / 43卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Martin Tobin and colleagues report a meta-analysis of 23 genome-wide association studies for pulmonary function. They identify 16 loci newly associated with variation in two cross-sectional measures of lung function, used to define airway obstruction and to grade the severity of obstruction.

引用

页码：1082 / 1090

页数：8

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