CD40-ligand in primate cardiac allograft and viral immunity

被引:0
|
作者
Richard N. Pierson
James E. Crowe
Steffen Pfeiffer
James Atkinson
Agnes Azimzadeh
Geraldine G. Miller
机构
[1] Vanderbilt University Medical Center and Nashville VAMC,Departments of Cardiothoracic Surgery, Pediatrics, Medicine, and Pathology
[2] 2986 The Vanderbilt Clinic,undefined
来源
Immunologic Research | 2001年 / 23卷
关键词
CD40L; CD154; Costimulation; Allograft; Heart; Cardiac; Influenza Virus; Transplant; Nonhuman Primate;
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学科分类号
摘要
Our laboratory has studied the role of CD40 ligand (CD40L, CD154) in the primate immune response to allogenic and infectious challenges. We find that intensive early blockade of CD40L reliably attenuates acute rejection of primate cardiac allografts. Monotherapy fails to prevent late graft loss, which often occurs in association with rising antidonor antibody titers and allograft vasculopathy, despite continuing anti-CD40L therapy. In contrast, the primary humoral response to T helper dependent influenze viral antigen is inhibited during anti-CD40L the rapy, and responses to subsequent immunization are blunted after discontinuation of therapy. These results are encouraging with regard to the tolerogenic potential of costimulatory blockade for specific T helper dependent antigens. However, these findings also indicate that pathogenic allograft responses in primates are probably not entirely CD40L-dependent. As such, additional immunomodulatory strategies are needed to facilitate tolerance to a transplanted organ.
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页码:253 / 262
页数:9
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