Functional prediction of long non-coding RNAs in ovarian cancer-associated fibroblasts indicate a potential role in metastasis

被引:0
|
作者
Fatemeh Vafaee
Emily K. Colvin
Samuel C. Mok
Viive M. Howell
Goli Samimi
机构
[1] School of Biotechnology and Biomolecular Sciences,
[2] University of New South Wales,undefined
[3] Bill Walsh Translational Cancer Research Laboratory,undefined
[4] Kolling Institute,undefined
[5] Northern Sydney Local Health District,undefined
[6] Sydney Medical School Northern,undefined
[7] University of Sydney,undefined
[8] Department of Gynecologic Oncology and Reproductive Medicine Research,undefined
[9] Division of Surgery,undefined
[10] The University of Texas MD Anderson Cancer Center,undefined
[11] Division of Cancer Prevention,undefined
[12] National Cancer Institute,undefined
[13] National Institutes of Health,undefined
来源
Scientific Reports | / 7卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Cancer-associated fibroblasts (CAFs) contribute to the poor prognosis of ovarian cancer. Unlike in tumour cells, DNA mutations are rare in CAFs, raising the likelihood of other mechanisms that regulate gene expression such as long non-coding RNAs (lncRNAs). We aimed to identify lncRNAs that contribute to the tumour-promoting phenotype of CAFs. RNA expression from 67 ovarian CAF samples and 10 normal ovarian fibroblast (NOF) samples were analysed to identify differentially expressed lncRNAs and a functional network was constructed to predict those CAF-specific lncRNAs involved in metastasis. Of the 1,970 lncRNAs available for analysis on the gene expression array used, 39 unique lncRNAs were identified as differentially expressed in CAFs versus NOFs. The predictive power of differentially expressed lncRNAs in distinguishing CAFs from NOFs were assessed using multiple multivariate models. Interrogation of known transcription factor-lncRNA interactions, transcription factor-gene interactions and construction of a context-specific interaction network identified multiple lncRNAs predicted to play a role in metastasis. We have identified novel lncRNAs in ovarian cancer that are differentially expressed in CAFs compared to NOFs and are predicted to contribute to the metastasis-promoting phenotype of CAFs.
引用
收藏
相关论文
共 50 条
  • [21] The functional role of long non-coding RNAs and epigenetics
    Jinneng Cao
    Biological Procedures Online, 2014, 16
  • [22] The Functional Role of Long Non-Coding RNAs in Melanoma
    Wozniak, Michal
    Czyz, Malgorzata
    CANCERS, 2021, 13 (19)
  • [23] The functional role of long non-coding RNAs and epigenetics
    Cao, Jinneng
    BIOLOGICAL PROCEDURES ONLINE, 2014, 16
  • [24] INVESTIGATING THE ROLE OF LONG NON-CODING RNAS IN CISPLATIN RESISTANCE IN OVARIAN CANCER
    Shah, Jaynish S.
    Cole, Alexander J.
    Dickson, Kristie-Ann
    Soon, Patsy
    Marsh, Deborah J.
    ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2014, 10 : 42 - 42
  • [25] The pivotal role of long non-coding RNAs as potential biomarkers and modulators of chemoresistance in ovarian cancer (OC)
    Malgundkar, Shika Hanif
    Tamimi, Yahya
    HUMAN GENETICS, 2024, 143 (02) : 107 - 124
  • [26] The pivotal role of long non-coding RNAs as potential biomarkers and modulators of chemoresistance in ovarian cancer (OC)
    Shika Hanif Malgundkar
    Yahya Tamimi
    Human Genetics, 2024, 143 : 107 - 124
  • [27] Non-coding RNAs as Putative Biomarkers of Cancer-Associated Cachexia
    Donzelli, Sara
    Farneti, Alessia
    Marucci, Laura
    Ganci, Federica
    Sacconi, Andrea
    Strano, Sabrina
    Sanguineti, Giuseppe
    Blandino, Giovanni
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
  • [28] Alternative Regulation of Cancer-Associated Genes through Modulation of Long Non-Coding RNAs
    Sage, A.
    Stewart, G.
    Anderson, C.
    Rowbotham, D.
    Enfield, K.
    Marshall, E.
    Martinez, V.
    Lam, W.
    JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (11) : S2105 - S2105
  • [29] Roles of long non-coding RNAs in gastric cancer metastasis
    Zi-Guo Yang
    Ling Gao
    Xiao-Bo Guo
    Yu-Long Shi
    World Journal of Gastroenterology, 2015, (17) : 5220 - 5230
  • [30] Long non-coding RNAs involved in metastasis of gastric cancer
    Meng-Ting Lin
    Hao-Jun Song
    Xiao-Yun Ding
    World Journal of Gastroenterology, 2018, 24 (33) : 3724 - 3737