Sex Differences in COMT Polymorphism Effects on Prefrontal Inhibitory Control in Adolescence

被引：0

作者：

Thomas P White

Eva Loth

Katya Rubia

Lydia Krabbendam

Robert Whelan

Tobias Banaschewski

Gareth J Barker

Arun LW Bokde

Christian Büchel

Patricia Conrod

Mira Fauth-Bühler

Herta Flor

Vincent Frouin

Jürgen Gallinat

Hugh Garavan

Penny Gowland

Andreas Heinz

Bernd Ittermann

Claire Lawrence

Karl Mann

Marie-Laure Paillère

Frauke Nees

Tomas Paus

Zdenka Pausova

Marcella Rietschel

Trevor Robbins

Michael N Smolka

Sukhwinder S Shergill

Gunter Schumann

机构：

[1] Institute of Psychiatry,Department of Psychosis Studies

[2] King's College London,Department of Child and Adolescent Psychiatry

[3] MRC Social,Department of Educational Neuroscience

[4] Genetic and Developmental Psychiatry Centre,Departments of Psychiatry and Psychology

[5] Institute of Psychiatry,Department of Cognitive and Clinical Neuroscience

[6] King's College London,Department of Psychiatry

[7] Institute of Psychiatry,Department of Addictive Behaviour and Addiction Medicine

[8] King's College London,Department of Psychiatry and Psychotherapy

[9] Faculty of Psychology and Education,Department of Physics and Astronomy

[10] VU University Amsterdam,AP

[11] Institute of Neuroscience,HP Department of Adolescent Psychopathology and Medicine

[12] Trinity College Dublin,Department of Experimental Psychology

[13] University of Vermont,Department of Psychiatry and Neuroimaging Center

[14] Central Institute of Mental Health,undefined

[15] Medical Faculty Mannheim,undefined

[16] Heidelberg University,undefined

[17] Institute of Psychiatry,undefined

[18] King’s College London,undefined

[19] Institute of Neuroscience and Discipline of Psychiatry,undefined

[20] School of Medicine,undefined

[21] Trinity College Dublin,undefined

[22] Universitaetsklinikum Hamburg Eppendorf,undefined

[23] Universite de Montreal,undefined

[24] CHU Ste Justine Hospital,undefined

[25] Heidelberg University,undefined

[26] Neurospin,undefined

[27] Commissariat à l'Energie Atomique et aux Energies Alternatives,undefined

[28] Campus Charité Mitte,undefined

[29] Charité—Universitätsmedizin Berlin,undefined

[30] University of Nottingham,undefined

[31] Physikalisch-Technische Bundesanstalt (PTB),undefined

[32] Braunschweig und Berlin,undefined

[33] School of Psychology,undefined

[34] University of Nottingham,undefined

[35] Institut National de la Santé et de la Recherche Médicale,undefined

[36] INSERM CEA Unit 1000 ‘Imaging & Psychiatry’,undefined

[37] University Paris Sud,undefined

[38] Maison de Solenn,undefined

[39] University Paris Descartes,undefined

[40] Rotman Research Institute,undefined

[41] University of Toronto,undefined

[42] Montreal Neurological Institute,undefined

[43] McGill University,undefined

[44] The Hospital for Sick Children,undefined

[45] University of Toronto,undefined

[46] Behavioural and Clinical Neurosciences Institute,undefined

[47] University of Cambridge,undefined

[48] Technische Universität Dresden,undefined

来源：

Neuropsychopharmacology | 2014年 / 39卷

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学科分类号：

摘要：

Catecholamine-0-methyl-transferase (COMT) gene variation effects on prefrontal blood oxygenation-level-dependent (BOLD) activation are robust; however, despite observations that COMT is estrogenically catabolized, sex differences in its prefrontal repercussions remain unclear. Here, in a large sample of healthy adolescents stratified by sex and Val158Met genotype (n=1133), we examine BOLD responses during performance of the stop-signal task in right-hemispheric prefrontal regions fundamental to inhibitory control. A significant sex-by-genotype interaction was observed in pre-SMA during successful-inhibition trials and in both pre-SMA and inferior frontal cortex during failed-inhibition trials with Val homozygotes displaying elevated activation compared with other genotypes in males but not in females. BOLD activation in the same regions significantly mediated the relationship between COMT genotype and inhibitory proficiency as indexed by stop-signal reaction time in males alone. These sexually dimorphic effects of COMT on inhibitory brain activation have important implications for our understanding of the contrasting patterns of prefrontally governed psychopathology observed in males and females.

引用

页码：2560 / 2569

页数：9

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