Reduced intensity conditioning regimen followed by glycosylated G-CSF mobilized PBSCT in patients with solid tumors and malignant lymphomas

被引:0
|
作者
L Castagna
A Bertuzzi
A Nozza
L Siracusano
M Balzarotti
M Magagnoli
B Sarina
I Timofeeva
M Sinnone
MG Grimoldi
M Farè
A Santoro
机构
[1] Istituto Clinico Humanitas,Department of Medical Oncology and Hematology
[2] Rozzano,undefined
[3] Centro Trasfusionale,undefined
[4] Ospedale S Paolo,undefined
[5] Cytogenetic Laboratory,undefined
[6] Ospedale Maggiore Policlinico,undefined
[7] Centro Trasfusionale e di Immunoematologia,undefined
[8] Istituto Ortopedico Gaetano Pini,undefined
来源
Bone Marrow Transplantation | 2002年 / 30卷
关键词
low intensity conditioning regimen; allogeneic transplantation; immunotherapy;
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学科分类号
摘要
The aim of this pilot study was to exploit the graft-versus-tumor potential of allogeneic transplants while improving safety of the procedure. Twelve patients with advanced hematological malignancies and solid tumors underwent a low intensity conditioning regimen (fludarabine and cyclophosphamide) followed by an allogeneic peripheral blood stem cell transplantation. The median time to achieve an absolute neutrophil count of more than 0.5 × 109/l and an untransfused platelet count of more than 20 × 109/l was 15 and 14 days, respectively. The main extra-hematological toxicities were mucositis and infections. Acute graft-versus-host (GVHD) disease was experienced by 62% of evaluable patients (grade II/B or III/C 80%) responsive to steroids. Extensive chronic GVHD was observed in 62% of patients. Non-relapse transplant-related mortality by day +30 was observed in three patients (25%). Eight out of 12 patients were full donor chimeric by day +100. One patient showed a mixed chimerism at day +37 when he died from progressive disease. One patient was in complete remission (CR) before allogeneic transplantation, and after transplantation four patients achieved CR and four experienced progressive disease. Our study confirms that a low intensity conditioning regimen for allogeneic stem cell transplantation is feasible and effective in heavily pretreated patients.
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页码:207 / 214
页数:7
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