Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27)

被引：0
|
作者：
D. Kaul
M. Kaur
机构：
[1] Postgraduate Institute of Medical Education and Research,Molecular Biology Unit, Department of Experimental Medicine and Biotechnology
来源：
Molecular and Cellular Biochemistry | 1999年 / 200卷
关键词：
mevalonate pathway; CDK inhibitors; Receptor-C; expression; TPA; HL-60 cell line;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present study was addressed to understand the interrelationship between Receptor-Ck induction-activation coupling; isoprenoids (derived from mevalonate pathway) and cyclin-dependent kinase inhibitors. The results reported here unambiguously reveal that isoprenoids regulate the expression of genes coding for CDK inhibited p16 and p27. Further, Receptor-Ck dependent signalling, known to control the mevalonate pathway, had a direct effect upon the p27 gene expression. Based upon these studies coupled with our earlier findings we propose that Receptor-Ck has an important role in the regulation of cell cycle machinery.
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页码：183 / 186
页数：3
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