A randomised phase II trial of temozolomide with or without cannabinoids in patients with recurrent glioblastoma (ARISTOCRAT): protocol for a multi-centre, double-blind, placebo-controlled trial

被引：0
|
作者：
Divyalakshmi Bhaskaran
Joshua Savage
Amit Patel
Fiona Collinson
Rhys Mant
Florien Boele
Lucy Brazil
Sara Meade
Peter Buckle
Siân Lax
Lucinda Billingham
Susan C. Short
机构：
[1] University of Leeds,School of Medicine
[2] Leeds Teaching Hospitals NHS Trust,Cancer Research UK Clinical Trials Unit (CRCTU), Institute of Cancer & Genomic Sciences
[3] University of Birmingham,undefined
[4] Guy’s and St Thomas’ NHS Foundation Trust,undefined
[5] University Hospitals Birmingham Foundation Trust,undefined
[6] The Brain Tumour Charity,undefined
来源：
BMC Cancer | / 24卷
关键词：
Randomised phase II trial; Glioblastoma; Cannabinoids; Sativex; Nabiximols; Brain cancer; Tumour; Temozolomide; Progression free survival; Overall survival; Adverse events;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [41] Multi-centre, randomised, double-blind, placebo-controlled trial of additive duloxetine for cancer-related neuropathic pain refractory to opioids and gabapentinoids
    Matsuoka, Hiromichi
    Iwase, Satoru
    Miyaji, Tempei
    Kawaguchi, Takashi
    Ariyoshi, Keisuke
    Oyamada, Shunsuke
    Satomi, Eriko
    Ishiki, Hiroto
    Hasuo, Hideaki
    Sakuma, Hiroko
    Tokoro, Akihiro
    Shinomiya, Toshiaki
    Otani, Hiroyuki
    Otake, Yoichi
    Hiroaki, Tsukuura
    Matsumoto, Yoshihisa
    Hasegawa, Yoshikazu
    Kataoka, Yuki
    Otsuka, Masatomo
    Sakai, Kiyohiro
    Matsuda, Yoshinobu
    Morita, Tatsuya
    Koyama, Atsuko
    Yamaguchi, Takuhiro
    ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2018, 14 : 161 - 162
  • [42] Methotrexate vs Placebo in Early Tubal Ectopic Pregnancy: A Multi-Centre Double-Blind Randomised Trial
    Casikar, Ishwari
    Lu, Chuan
    Reid, Shannon
    Bignardi, Tommaso
    Mongelli, Max
    Morris, Alastair
    Wild, Richard
    Condous, George
    REVIEWS ON RECENT CLINICAL TRIALS, 2012, 7 (03) : 238 - 243
  • [43] Metformin for knee osteoarthritis with obesity: study protocol for a randomised, double-blind, placebo-controlled trial
    Lim, Yuan Z.
    Wang, Yuanyuan
    Urquhart, Donna M.
    Estee, Mahnuma Mahfuz
    Wluka, Anita E.
    Heritier, Stephane
    Cicuttini, Flavia M.
    BMJ OPEN, 2023, 13 (12):
  • [44] Metformin for low back pain: Study protocol for a randomised, double-blind, placebo-controlled trial
    Lim, Yuan Z.
    Urquhart, Donna M.
    Wang, Yuanyuan
    Estee, Mahnuma Mahfuz
    Wluka, Anita E.
    Heritier, Stephane
    Cicuttini, Flavia M.
    OSTEOARTHRITIS AND CARTILAGE OPEN, 2025, 7 (01):
  • [45] Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial
    Kordes, Sil
    Pollak, Michael N.
    Zwinderman, Aeilko H.
    Mathot, Ron A.
    Weterman, Mariette J.
    Beeker, Aart
    Punt, Cornelis J.
    Richel, Dick J.
    Wilmink, Johanna W.
    LANCET ONCOLOGY, 2015, 16 (07): : 839 - 847
  • [46] Efficacy and safety of pegzilarginase in arginase 1 deficiency (PEACE): a phase 3, randomized, double-blind, placebo-controlled, multi-centre trial
    Russo, Rossana Sanchez
    Gasperini, Serena
    Bubb, Gillian
    Neuman, Linda
    Sloan, Leslie S.
    Diaz, George A.
    Enns, Gregory M.
    ECLINICALMEDICINE, 2024, 68
  • [47] Efficacy of halopeRIdol to decrease the burden of Delirium In adult Critically ill patiEnts (EuRIDICE): study protocol for a prospective randomised multi-centre double-blind placebo-controlled clinical trial in the Netherlands
    Smit, Lisa
    Trogrlic, Zoran
    Devlin, John W.
    Osse, Robert-Jan
    Ponssen, Huibert H.
    Slooter, Arjen J. C.
    Hunfeld, Nicole G. M.
    Rietdijk, Wim J. R.
    Gommers, Diederik
    van der Jagt, Mathieu
    van den Boogaard, M.
    Brouwers, A. J. B. W.
    Lens, J. A.
    van der Meer, B. J. M.
    Ponssen, H.
    Schoonderbeek, F. J.
    Simons, K. S.
    Berger, E.
    Bouman, A.
    Campo, M.
    van Duijn, D.
    Donk, H. Embden-van
    van de Graaf, D.
    Hoogendoorn, E.
    Ormskerk, P.
    Roovers, N.
    Toscano, E.
    Vileito, A.
    van Zuylen, T.
    Exler, C.
    van den Berg, E.
    van Meeteren, J.
    Koopmanschap, M.
    BMJ OPEN, 2020, 10 (09):
  • [48] CONFIRM: a double-blind, placebo-controlled phase III clinical trial investigating the effect of nivolumab in patients with relapsed mesothelioma: study protocol for a randomised controlled trial
    Dean A. Fennell
    Emma Kirkpatrick
    Kelly Cozens
    Mavis Nye
    Jason Lester
    Gerard Hanna
    Nicola Steele
    Peter Szlosarek
    Sarah Danson
    Joanne Lord
    Christian Ottensmeier
    Daniel Barnes
    Stephanie Hill
    Mihalis Kalevras
    Tom Maishman
    Gareth Griffiths
    Trials, 19
  • [49] Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial
    Madisch, A
    Holtmann, G
    Plein, K
    Hotz, J
    ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2004, 19 (03) : 271 - 279
  • [50] HOMOCYSTEINE AND MENTAL HEALTH IN OLDER PATIENTS: A RANDOMISED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL
    Gariballa, S. E.
    AGE AND AGEING, 2011, 40 : II11 - II11
12345